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Qrfp Gene Detail
Summary
  • Symbol
    Qrfp
  • Name
    pyroglutamylated RFamide peptide
  • Synonyms
    P518, QRFP
  • Feature Type
    protein coding gene
  • IDs
    MGI:3630329
    NCBI Gene: 227717
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:31696180-31700592 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3630329
 protein coding gene Chr2:31696178-31700592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025590
 protein coding gene Chr2:30184901-30190979 (-)
A/J MGP_AJ_G0025568
 protein coding gene Chr2:28934687-28939100 (-)
AKR/J MGP_AKRJ_G0025537
 protein coding gene Chr2:29929529-29933942 (-)
BALB/cJ MGP_BALBcJ_G0025564
 protein coding gene Chr2:29061855-29066302 (-)
C3H/HeJ MGP_C3HHeJ_G0025325
 protein coding gene Chr2:29843366-29848967 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026009
 protein coding gene Chr2:31127045-31131448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023417
 protein coding gene Chr2:27679388-27683747 (-)
CAST/EiJ MGP_CASTEiJ_G0024787
 protein coding gene Chr2:29786650-29793002 (-)
CBA/J MGP_CBAJ_G0025302
 protein coding gene Chr2:32259186-32263586 (-)
DBA/2J MGP_DBA2J_G0025435
 protein coding gene Chr2:28708999-28713412 (-)
FVB/NJ MGP_FVBNJ_G0025398
 protein coding gene Chr2:28559919-28563946 (-)
LP/J MGP_LPJ_G0025521
 protein coding gene Chr2:30058828-30064709 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025428
 protein coding gene Chr2:31994432-32000318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026067
 protein coding gene Chr2:29844263-29849354 (-)
PWK/PhJ MGP_PWKPhJ_G0024534
 protein coding gene Chr2:28599444-28603990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024334
 protein coding gene Chr2:29981950-29988366 (-)
WSB/EiJ MGP_WSBEiJ_G0024855
 protein coding gene Chr2:30018968-30024838 (-)



Homology
more
  • Human Ortholog
    QRFP, pyroglutamylated RFamide peptide
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QRFP, pyroglutamylated RFamide peptide
  • Synonyms
    26RFa, P518
  • Links
    NCBI Gene ID: 347148
    neXtProt AC: NX_P83859
    UniProt: P83859

  • Chr Location
    9q34.12; chr9:130892707-130896812 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and fat mass, hypophagia, decreased serum leptin level, hypoactivity, increased anxiety-like behavior, and decreased wakefulness in the early hours of the dark period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227717 NCBI Gene Model | MGI Sequence Detail 4413 C57BL/6J ±  kb
    transcript NM_183424 RefSeq | MGI Sequence Detail 2925 C57BL/6  
    polypeptide Q8CE23 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:84528 Jiang Y, et al., Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem. 2003 Jul 25;278(30):27652-7
    • Latest
      J:328321 El Mehdi M, et al., The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis. Diabetologia. 2022 Jul;65(7):1198-1211
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory