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Mirlet7a-2 Gene Detail
Summary
  • Symbol
    Mirlet7a-2
  • Name
    microRNA let7a-2
  • Synonyms
    let 7a-2, Mirnlet7a-2, mmu-let-7a-2
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619049
    NCBI Gene: 723965
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:41448012-41448107 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 23.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619049
miRNA gene Chr9:41448012-41448107 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009194
miRNA gene Chr9:39833377-39833472 (+)
A/J MGP_AJ_G0009174
miRNA gene Chr9:38786875-38786970 (+)
AKR/J MGP_AKRJ_G0009164
miRNA gene Chr9:39524171-39524266 (+)
BALB/cJ MGP_BALBcJ_G0009159
miRNA gene Chr9:38533788-38533883 (+)
C3H/HeJ MGP_C3HHeJ_G0009099
miRNA gene Chr9:40043139-40043234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009401
miRNA gene Chr9:41083918-41084013 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008260
miRNA gene Chr9:38414126-38414221 (+)
CAST/EiJ MGP_CASTEiJ_G0008932
miRNA gene Chr9:39801596-39801691 (+)
CBA/J MGP_CBAJ_G0009067
miRNA gene Chr9:42517373-42517468 (+)
DBA/2J MGP_DBA2J_G0009098
miRNA gene Chr9:38712120-38712215 (+)
FVB/NJ MGP_FVBNJ_G0009114
miRNA gene Chr9:37944296-37944391 (+)
LP/J MGP_LPJ_G0009192
miRNA gene Chr9:40096026-40096121 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009080
miRNA gene Chr9:44550873-44550968 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009370
miRNA gene Chr9:39451264-39451359 (+)
PWK/PhJ MGP_PWKPhJ_G0008857
miRNA gene Chr9:38538999-38539094 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008698
miRNA gene Chr9:39685598-39685693 (+)
WSB/EiJ MGP_WSBEiJ_G0009026
miRNA gene Chr9:39482756-39482851 (+)



Homology
more
  • Human Ortholog
    MIRLET7A2, microRNA let-7a-2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIRLET7A2, microRNA let-7a-2
  • Synonyms
    let-7a-2, LET7A2, MIRNLET7A2
  • Links
    NCBI Gene ID: 406882

  • Chr Location
    chr11:122146522-122146593 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 723965 NCBI Gene Model | MGI Sequence Detail 96 C57BL/6J ±  kb
transcript NR_029726 RefSeq | MGI Sequence Detail 96 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 9
    Primer pair 6
    Other 3
Other Database
Links
less
miRBase MI0000557
References
more
  • Summaries
    All 55
    Developmental Gene Expression 30
    Gene Ontology 10
    Phenotypes 1
  • Earliest
    J:93952 Mansfield JH, et al., MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct;36(10):1079-83
  • Latest
    J:341352 Wells AC, et al., Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation. Nat Commun. 2023 Sep 11;14(1):5585

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory