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Mir1a-2 Gene Detail
Summary
  • Symbol
    Mir1a-2
  • Name
    microRNA 1a-2
  • Synonyms
    mir 1-2, Mirn1-2, mmu-mir-1-2, mmu-mir-1a-2
Location &
Maps
more
  • Sequence Map
    Chr18:10785481-10785552 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 5.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3618746
 miRNA gene Chr18:10785481-10785552 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008369
 miRNA gene Chr18:7728051-7728122 (-)
A/J MGP_AJ_G0008358
 miRNA gene Chr18:7675944-7676015 (-)
AKR/J MGP_AKRJ_G0008342
 miRNA gene Chr18:7877769-7877840 (-)
BALB/cJ MGP_BALBcJ_G0008342
 miRNA gene Chr18:7660374-7660445 (-)
C3H/HeJ MGP_C3HHeJ_G0008287
 miRNA gene Chr18:7770883-7770954 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008541
 miRNA gene Chr18:8182426-8182497 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007582
 miRNA gene Chr18:7353022-7353093 (-)
CAST/EiJ MGP_CASTEiJ_G0008151
 miRNA gene Chr18:7666929-7667000 (-)
CBA/J MGP_CBAJ_G0008254
 miRNA gene Chr18:8243421-8243492 (-)
DBA/2J MGP_DBA2J_G0008285
 miRNA gene Chr18:7543787-7543858 (-)
FVB/NJ MGP_FVBNJ_G0008309
 miRNA gene Chr18:7491450-7491521 (-)
LP/J MGP_LPJ_G0008371
 miRNA gene Chr18:7855240-7855311 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008273
 miRNA gene Chr18:8489085-8489156 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008530
 miRNA gene Chr18:7708969-7709040 (-)
PWK/PhJ MGP_PWKPhJ_G0008071
 miRNA gene Chr18:7576767-7576838 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0008232
 miRNA gene Chr18:7683746-7683817 (-)



Homology
more
  • Human Ortholog
    MIR1-2, microRNA 1-2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR1-2, microRNA 1-2
  • Synonyms
    hsa-mir-1-2, mir-1-2, MIRN1-2, miRNA1-2
  • Links
    NCBI Gene ID: 406905

  • Chr Location
    chr18:21829004-21829088 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show pericardial edema and impaired cardiac morphogenesis and electrophysiology, including ventricular septal defects in a subset that suffer early lethality, and reduced heart rate and cell cycle defects leading to hyperplasia in surviving adults. About 50% die by weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    28
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      25
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723959 NCBI Gene Model | MGI Sequence Detail 72 C57BL/6J ±  kb
    transcript NR_029781 RefSeq | MGI Sequence Detail 72 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      Primer pair 2
      Other 6
    Other Database
    Links
    less
    miRBase MI0000652
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 30
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:93952 Mansfield JH, et al., MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct;36(10):1079-83
    • Latest
      J:328212 Klockner I, et al., Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. Nat Commun. 2022 Jun 8;13(1):3180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory