Aoc1l1 MGI Mouse Gene Detail - MGI:3618290 - amine oxidase copper containing 1-like 1

Symbol

Aoc1l1
Name

amine oxidase copper containing 1-like 1
Synonyms

Doxl2

Feature Type

protein coding gene
IDs

MGI:3618290
NCBI Gene: 243376
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:48951897-48955680 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.82 cM
Mapping Data

1 experiment

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3618290	protein coding gene	Chr6:48951880-48955680 (+)
129S1/SvImJ	ENSMUSG00200005039	protein coding gene	Chr6:45857700-45861483 (+)
A/J	ENSMUSG00195006383	protein coding gene	Chr6:45627906-45631690 (+)
AKR/J	ENSMUSG00220002875	protein coding gene	Chr6:45338298-45342081 (+)
BALB/cJ	ENSMUSG00180022924	protein coding gene	Chr6:45941739-45945522 (+)
C3H/HeJ	ENSMUSG00175016627	protein coding gene	Chr6:45703327-45707110 (+)
C57BL/6NJ	ENSMUSG00215005712	protein coding gene	Chr6:45902743-45906526 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028360	protein coding gene	Chr6:43380930-43384701 (+)
CAST/EiJ	ENSTCUG00005004773	protein coding gene	Chr6:45211527-45215324 (+)
CBA/J	ENSMUSG00210017567	protein coding gene	Chr6:45748177-45751960 (+)
DBA/2J	ENSMUSG00185012458	protein coding gene	Chr6:46329888-46333671 (+)
FVB/NJ	ENSMUSG00205021664	protein coding gene	Chr6:45994368-45998151 (+)
JF1/MsJ	ENSUMUG00000011897	protein coding gene	Chr6:45704788-45708587 (+)
LP/J	ENSMUSG00230013964	protein coding gene	Chr6:47354778-47358561 (+)
NOD/ShiLtJ	ENSMUSG00190024535	protein coding gene	Chr6:45667127-45670911 (+)
NZO/HlLtJ	ENSMUSG00225018405	protein coding gene	Chr6:49391365-49395148 (+)
PWK/PhJ	ENSLUMG00010019052	protein coding gene	Chr6:45329185-45332988 (+)
SPRET/EiJ	ENSMSPG00010008102	protein coding gene	Chr6:45941472-45945273 (+)
WSB/EiJ	ENSIUOG00005025126	protein coding gene	Chr6:45963802-45967586 (+)

Human Ortholog

AOC1, amine oxidase copper containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AOC1, amine oxidase copper containing 1
Synonyms

ABP, ABP1, DAO, DAO1, KAO, KDAO
Links

HGNC:80

NCBI Gene ID: 26

UniProt: P19801
Chr Location

7q36.1; chr7:150824627-150861504 (+) GRCh38

MGI Vertebrate Homology

Aoc1l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AOC1
Gene Tree

Aoc1l1

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

603
Tissues

4
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

35
RefSeq

3
UniProt

4
CCDS

CCDS20120.1

Ensembl

ENSMUSG00000068536 (Evidence)
NCBI Gene

243376

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068536	Ensembl Gene Model \| MGI Sequence Detail	3784	C57BL/6J	± kb
transcript	ENSMUST00000184917	Ensembl \| MGI Sequence Detail	2468	Not Applicable
polypeptide	ENSMUSP00000139012	Ensembl \| MGI Sequence Detail	723	Not Applicable

less

UniProt

4 Sequences
EC

1.4.3.-
InterPro Domains

IPR000269 Copper amine oxidase

IPR015798 Copper amine oxidase, catalytic domain

IPR036460 Copper amine oxidase, catalytic domain superfamily

IPR015800 Copper amine oxidase, N2-terminal

IPR015802 Copper amine oxidase, N3-terminal

IPR016182 Copper amine oxidase, N-terminal
GlyGen

Q6IMK7 1 site

less

All nucleic 15

cDNA 15

Microarray probesets 1

less

MGI:6718883

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 7
Earliest

J:86672 Lundwall A, et al., Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidases. Biol Reprod. 2003 Dec;69(6):1923-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aoc1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56259	Chr6:48951867-48951894 (+)	-16 bp
Tssr56260	Chr6:48954076-48954082 (+)	2,182 bp
Tssr56261	Chr6:48954092-48954097 (+)	2,198 bp
Tssr56262	Chr6:48954165-48954208 (+)	2,290 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24