Ano3 MGI Mouse Gene Detail - MGI:3613666

Symbol

Ano3
Name

anoctamin 3
Synonyms

B230324K02Rik, Tmem16c

Feature Type

protein coding gene
IDs

MGI:3613666
NCBI Gene: 228432
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:110485546-110780854 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 56.75 cM
Mapping Data

2 experiments

SNPs within 2kb

9007 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3613666	protein coding gene	Chr2:110485546-110781268 (-)
129S1/SvImJ	ENSMUSG00200006707	protein coding gene	Chr2:107377386-107672642 (-)
A/J	ENSMUSG00195030299	protein coding gene	Chr2:107451659-107746951 (-)
AKR/J	ENSMUSG00220004579	protein coding gene	Chr2:107292251-107588049 (-)
BALB/cJ	ENSMUSG00180030498	protein coding gene	Chr2:107246827-107542109 (-)
C3H/HeJ	ENSMUSG00175031369	protein coding gene	Chr2:107634313-107935763 (-)
C57BL/6NJ	ENSMUSG00215016528	protein coding gene	Chr2:107379564-107675343 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024054	protein coding gene	Chr2:103780800-104066351 (-)
CAST/EiJ	ENSTCUG00005005379	protein coding gene	Chr2:106635899-106928174 (-)
CBA/J	ENSMUSG00210033607	protein coding gene	Chr2:107520973-107816258 (-)
DBA/2J	ENSMUSG00185037089	protein coding gene	Chr2:107243257-107538545 (-)
FVB/NJ	ENSMUSG00205015646	protein coding gene	Chr2:106549471-106844775 (-)
JF1/MsJ	ENSUMUG00000001690	protein coding gene	Chr2:107035974-107332286 (-)
LP/J	ENSMUSG00230005222	protein coding gene	Chr2:109039714-109334980 (-)
NOD/ShiLtJ	ENSMUSG00190015234	protein coding gene	Chr2:107464698-107759980 (-)
NZO/HlLtJ	ENSMUSG00225012341	protein coding gene	Chr2:116939638-117234898 (-)
PWK/PhJ	ENSLUMG00010002954	protein coding gene	Chr2:107017059-107313583 (-)
SPRET/EiJ	ENSMSPG00010031747	protein coding gene	Chr2:109240929-109585608 (-)
WSB/EiJ	ENSIUOG00005031431	protein coding gene	Chr2:107122702-107422368 (-)

Human Ortholog

ANO3, anoctamin 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANO3, anoctamin 3
Synonyms

C11orf25, DYT23, DYT24, GENX-3947, TMEM16C
Links

HGNC:14004

NCBI Gene ID: 63982

UniProt: Q9BYT9
Chr Location

11p14.3-p14.2; chr11:26188808-26663289 (+) GRCh38

MGI Vertebrate Homology

Ano3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANO3
Gene Tree

Ano3

Diseases

1 with human ANO3 associations

				Human Disease	Mouse Models
				dystonia 24 IDs dystonia 24 DOID:0090052 ICD10CM:G24.8 OMIM:615034 ORDO:420485

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Ano3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with brain-specific or Ptgds-expressing cell knock-out display greater susceptibility of hyperthermia-induced seizures and deficiency in thermoregulation.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

88
cDNA Data

3
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ano3

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All Sequences

50
RefSeq

18
UniProt

2
CCDS

CCDS50657.1, CCDS50658.1

Ensembl

ENSMUSG00000074968 (Evidence)
NCBI Gene

228432

			Length	Strain/Species	Flank
genomic	228432	NCBI Gene Model \| MGI Sequence Detail	295309	C57BL/6J	± kb
transcript	NM_001128103	RefSeq \| MGI Sequence Detail	6026	C57BL/6
polypeptide	A2AHL1	UniProt \| EBI \| MGI Sequence Detail	981	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004058 anoctamin-3

(term hierarchy)
InterPro Domains

IPR007632 Anoctamin

IPR032394 Anoctamin, dimerisation domain

IPR049452 Anoctamin, transmembrane domain
GlyGen

A2AHL1 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 5

cDNA 3

Primer pair 2

Microarray probesets 4

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MGI:2139060, MGI:3045304

Summaries

All 43

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:388147 Xia W, et al., Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair. Nature. 2026 May;653(8115):819-830

TSS for Ano3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25620	Chr2:110780687-110780698 (-)	161 bp
Tssr25619	Chr2:110780567-110780648 (-)	246 bp
Tssr25618	Chr2:110780538-110780551 (-)	309 bp
Tssr25617	Chr2:110780504-110780514 (-)	345 bp
Tssr25616	Chr2:110670461-110670499 (-)	110,374 bp
Tssr25615	Chr2:110670400-110670407 (-)	110,450 bp
Tssr25614	Chr2:110670366-110670385 (-)	110,478 bp
Tssr25613	Chr2:110621574-110621577 (-)	159,278 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29