Redic1 MGI Mouse Gene Detail - MGI:3613655 - regulator of DNA class I crossover intermediates 1

Symbol

Redic1
Name

regulator of DNA class I crossover intermediates 1
Synonyms

CN725425, Gm5807

Feature Type

protein coding gene
IDs

MGI:3613655
NCBI Gene: 545126
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:91083697-91145097 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 46.04 cM
Mapping Data

2 experiments

SNPs within 2kb

2097 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3613655	protein coding gene	Chr15:91083654-91146291 (+)
129S1/SvImJ	ENSMUSG00200035190	protein coding gene	Chr15:88237661-88299140 (+)
A/J	ENSMUSG00195018768	protein coding gene	Chr15:88131200-88192643 (+)
AKR/J	ENSMUSG00220026226	protein coding gene	Chr15:88179703-88241110 (+)
BALB/cJ	ENSMUSG00180014575	protein coding gene	Chr15:88010703-88072100 (+)
C3H/HeJ	ENSMUSG00175024002	protein coding gene	Chr15:88317648-88379097 (+)
C57BL/6NJ	ENSMUSG00215028199	protein coding gene	Chr15:88121345-88182744 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020183	protein coding gene	Chr15:85057761-85118763 (+)
CAST/EiJ	ENSTCUG00005029785	protein coding gene	Chr15:87600926-87667713 (+)
CBA/J	ENSMUSG00210013097	protein coding gene	Chr15:88087098-88148543 (+)
DBA/2J	ENSMUSG00185021627	protein coding gene	Chr15:88103045-88164491 (+)
FVB/NJ	ENSMUSG00205030239	protein coding gene	Chr15:87859478-87920935 (+)
JF1/MsJ	ENSUMUG00000017407	protein coding gene	Chr15:87640731-87701953 (+)
LP/J	ENSMUSG00230043220	protein coding gene	Chr15:91460016-91521490 (+)
NOD/ShiLtJ	ENSMUSG00190025401	protein coding gene	Chr15:88132261-88193706 (+)
NZO/HlLtJ	ENSMUSG00225041332	protein coding gene	Chr15:91774308-91835776 (+)
PWK/PhJ	ENSLUMG00010033525	protein coding gene	Chr15:87796750-87857981 (+)
SPRET/EiJ	ENSMSPG00010012556	protein coding gene	Chr15:89587184-89647721 (+)
WSB/EiJ	ENSIUOG00005010216	protein coding gene	Chr15:88189794-88251297 (+)

Human Ortholog

REDIC1, regulator of DNA class I crossover intermediates 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REDIC1, regulator of DNA class I crossover intermediates 1
Synonyms

C12orf40, HEIP1, HEL-206, HEL-S-94
Links

HGNC:26846

NCBI Gene ID: 283461

UniProt: Q86WS4
Chr Location

12q12; chr12:39626167-39908300 (+) GRCh38

MGI Vertebrate Homology

Redic1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: REDIC1
Gene Tree

Redic1

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References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Genomic Mutations

3 involving Redic1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in allele that mimics a human mutation found in azoospermic patients are infertile in both sexes due to insufficient crossovers and consequent meiotic arrest. Spermatocytes show chromosomal synaptic defects, a reduction in recombination intermediates, and impaired double-strand DNA break repair.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

609
Tissues

8
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Expression Atlas
Other Vertebrate Links

Xenbase redic1

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All Sequences

30
RefSeq

2
UniProt

2

Ensembl

ENSMUSG00000078932 (Evidence)
NCBI Gene

545126

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078932	Ensembl Gene Model \| MGI Sequence Detail	61401	C57BL/6J	± kb
transcript	ENSMUST00000190436	Ensembl \| MGI Sequence Detail	2041	Not Applicable
polypeptide	ENSMUSP00000140772	Ensembl \| MGI Sequence Detail	652	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR027883 Regulator of DNA class I crossover intermediates 1-like

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All nucleic 6

cDNA 5

Primer pair 1

Antibodies 1

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MGI:3779525, MGI:7562015

Summaries

All 33

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 22
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Redic1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132709	Chr15:91083656-91083665 (+)	-36 bp
Tssr132710	Chr15:91083679-91083700 (+)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24