Tmprss9 MGI Mouse Gene Detail - MGI:3612246 - transmembrane protease, serine 9

Symbol

Tmprss9
Name

transmembrane protease, serine 9
Synonyms

Serase-1B

Feature Type

protein coding gene
IDs

MGI:3612246
NCBI Gene: 432478
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:80707682-80735326 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

1 experiment

SNPs within 2kb

105 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3612246	protein coding gene	Chr10:80706951-80735329 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017526	protein coding gene	Chr10:81548920-81570144 (+)
A/J	MGP_AJ_G0017504	protein coding gene	Chr10:78672601-78692769 (+)
AKR/J	MGP_AKRJ_G0017465	protein coding gene	Chr10:80829029-80850825 (+)
BALB/cJ	MGP_BALBcJ_G0017466	protein coding gene	Chr10:78888422-78908105 (+)
C3H/HeJ	MGP_C3HHeJ_G0017289	protein coding gene	Chr10:80920168-80941584 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017920	protein coding gene	Chr10:84344812-84367752 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015609	protein coding gene	Chr10:74882872-74902909 (+)
CAST/EiJ	MGP_CASTEiJ_G0016856	protein coding gene	Chr10:81148583-81169938 (+)
CBA/J	MGP_CBAJ_G0017261	protein coding gene	Chr10:87621582-87641247 (+)
DBA/2J	MGP_DBA2J_G0017367	protein coding gene	Chr10:77870219-77890184 (+)
FVB/NJ	MGP_FVBNJ_G0017361	protein coding gene	Chr10:77103920-77123470 (+)
LP/J	MGP_LPJ_G0017438	protein coding gene	Chr10:82002447-82022243 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017387	protein coding gene	Chr10:89527731-89547433 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017961	protein coding gene	Chr10:80822892-80842896 (+)
PWK/PhJ	MGP_PWKPhJ_G0016637	protein coding gene	Chr10:77764347-77784823 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016427	protein coding gene	Chr10:79771804-79793874 (+)
WSB/EiJ	MGP_WSBEiJ_G0016916	protein coding gene	Chr10:80862824-80882352 (+)

Human Ortholog

TMPRSS9, transmembrane serine protease 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMPRSS9, transmembrane serine protease 9
Links

HGNC:30079

NCBI Gene ID: 360200

neXtProt AC: NX_Q7Z410

UniProt: Q7Z410
Chr Location

19p13.3; chr19:2360238-2426261 (+) GRCh38

MGI Vertebrate Homology

Tmprss9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMPRSS9
Protein SuperFamily

TMPRSS9_polyserase-1
Gene Tree

Tmprss9

Diseases

1 with Tmprss9 mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Tmprss9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show decreased social interest and social recognition and aged females show a borderline recognition memory deficit.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmprss9

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All Sequences

44
RefSeq

10
UniProt

4
CCDS

CCDS48641.1

Ensembl

ENSMUSG00000059406 (Evidence)
NCBI Gene

432478

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059406	Ensembl Gene Model \| MGI Sequence Detail	27645	C57BL/6J	± kb
transcript	ENSMUST00000105333	Ensembl \| MGI Sequence Detail	3497	Not Applicable
polypeptide	ENSMUSP00000100970	Ensembl \| MGI Sequence Detail	1099	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003051 transmembrane protease serine 9

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR036055 LDL receptor-like superfamily

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR000082 SEA domain

IPR036364 SEA domain superfamily

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

IPR017324 Transmembrane protease serine 9

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 24

Diseases 1

Gene Ontology 3

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmprss9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94634	Chr10:80707634-80707658 (+)	-36 bp
Tssr94635	Chr10:80707670-80707686 (+)	-4 bp
Tssr94636	Chr10:80710075-80710081 (+)	2,396 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23