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Nlrc5 Gene Detail
Summary
  • Symbol
    Nlrc5
  • Name
    NLR family, CARD domain containing 5
  • Synonyms
    AI451557
  • Feature Type
    protein coding gene
  • IDs
    MGI:3612191
    NCBI Gene: 434341
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95160984-95253900 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3612191
protein coding gene Chr8:95160963-95253900 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033961
protein coding gene Chr8:95853546-95955295 (+)
A/J MGP_AJ_G0033944
protein coding gene Chr8:92150753-92214341 (+)
AKR/J MGP_AKRJ_G0033870
protein coding gene Chr8:94677249-94731032 (+)
BALB/cJ MGP_BALBcJ_G0033936
protein coding gene Chr8:92249788-92305101 (+)
C3H/HeJ MGP_C3HHeJ_G0033646
protein coding gene Chr8:95391984-95447043 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034457
protein coding gene Chr8:99392722-99451285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031398
protein coding gene Chr8:85942984-86017358 (+)
CAST/EiJ MGP_CASTEiJ_G0032978
protein coding gene Chr8:94944467-95031061 (+)
CBA/J MGP_CBAJ_G0033622
protein coding gene Chr8:102690249-102752514 (+)
DBA/2J MGP_DBA2J_G0033776
protein coding gene Chr8:91628004-91683010 (+)
FVB/NJ MGP_FVBNJ_G0033723
protein coding gene Chr8:90594936-90649455 (+)
LP/J MGP_LPJ_G0033868
protein coding gene Chr8:96037926-96097705 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033765
protein coding gene Chr8:104949995-105045314 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034475
protein coding gene Chr8:94801420-94901678 (+)
PWK/PhJ MGP_PWKPhJ_G0032680
protein coding gene Chr8:90967329-91055496 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032517
protein coding gene Chr8:93658175-93722596 (+)
WSB/EiJ MGP_WSBEiJ_G0033090
protein coding gene Chr8:95333540-95427887 (+)



Homology
more
  • Human Ortholog
    NLRC5, NLR family CARD domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRC5, NLR family CARD domain containing 5
  • Synonyms
    CLR16.1, NOD27, NOD4
  • Links
    NCBI Gene ID: 84166
    neXtProt AC: NX_Q86WI3
    UniProt: Q86WI3

  • Chr Location
    16q13; chr16:56989485-57083531 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074151 Ensembl Gene Model | MGI Sequence Detail 92917 C57BL/6J ±  kb
    transcript ENSMUST00000211816 Ensembl | MGI Sequence Detail 7578 Not Applicable  
    polypeptide ENSMUSP00000148677 Ensembl | MGI Sequence Detail 1915 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011263 protein NLRC5
    • PDB
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR006553 Leucine-rich repeat, cysteine-containing subtype
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR041210 NLRC5, atypical caspase recruitment domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 42
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142553
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:343973 Bauer S, et al., NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARgamma target genes. iScience. 2023 Apr 21;26(4):106313

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory