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Pp2d1 Gene Detail
Summary
  • Symbol
    Pp2d1
  • Name
    protein phosphatase 2C-like domain containing 1
  • Synonyms
    4921523A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3612067
    NCBI Gene: 110332
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:53814488-53846479 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 27.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3612067
 protein coding gene Chr17:53814488-53846479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023888
 protein coding gene Chr17:55061142-55106293 (-)
A/J MGP_AJ_G0023848
 protein coding gene Chr17:53518604-53551604 (-)
AKR/J MGP_AKRJ_G0023816
 protein coding gene Chr17:54142607-54177770 (-)
BALB/cJ MGP_BALBcJ_G0023850
 protein coding gene Chr17:53395596-53428652 (-)
C3H/HeJ MGP_C3HHeJ_G0023613
 protein coding gene Chr17:54867105-54900888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024294
 protein coding gene Chr17:57195509-57225858 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021742
 protein coding gene Chr17:50118139-50152337 (-)
CAST/EiJ MGP_CASTEiJ_G0023095
 protein coding gene Chr17:55177351-55220024 (-)
CBA/J MGP_CBAJ_G0023589
 protein coding gene Chr17:59315046-59348266 (-)
DBA/2J MGP_DBA2J_G0023718
 protein coding gene Chr17:52281101-52312978 (-)
FVB/NJ MGP_FVBNJ_G0023684
 protein coding gene Chr17:51917038-51924807 (-)
LP/J MGP_LPJ_G0023798
 protein coding gene Chr17:55767843-55809658 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023712
 protein coding gene Chr17:58743216-58780800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024339
 protein coding gene Chr17:54453465-54489464 (-)
PWK/PhJ MGP_PWKPhJ_G0022840
 protein coding gene Chr17:51746440-51789483 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023159
 protein coding gene Chr17:55120683-55158818 (-)



Homology
more
  • Human Ortholog
    PP2D1, protein phosphatase 2C like domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PP2D1, protein phosphatase 2C like domain containing 1
  • Synonyms
    C3orf48
  • Links
    NCBI Gene ID: 151649
    neXtProt AC: NX_A8MPX8
    UniProt: A8MPX8

  • Chr Location
    3p24.3; chr3:19979961-20012267 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 110332 NCBI Gene Model | MGI Sequence Detail 31992 C57BL/6J ±  kb
transcript NM_173449 RefSeq | MGI Sequence Detail 2476 C57BL/6  
polypeptide Q8BVT6 UniProt | EBI | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:295177 Robertson MJ, et al., Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. BMC Biol. 2020 Aug 19;18(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory