Rapgefl1 MGI Mouse Gene Detail - MGI:3611446 - Rap guanine nucleotide exchange factor (GEF)-like 1

Symbol

Rapgefl1
Name

Rap guanine nucleotide exchange factor (GEF)-like 1

Feature Type

protein coding gene
IDs

MGI:3611446
NCBI Gene: 268480
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:98727611-98744519 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.70 cM
Mapping Data

1 experiment

SNPs within 2kb

442 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3611446	protein coding gene	Chr11:98727611-98744523 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019075	protein coding gene	Chr11:101446713-101469175 (+)
A/J	MGP_AJ_G0019043	protein coding gene	Chr11:97193764-97210602 (+)
AKR/J	MGP_AKRJ_G0019013	protein coding gene	Chr11:100204144-100220976 (+)
BALB/cJ	MGP_BALBcJ_G0019017	protein coding gene	Chr11:97690463-97707785 (+)
C3H/HeJ	MGP_C3HHeJ_G0018830	protein coding gene	Chr11:100351098-100368822 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019468	protein coding gene	Chr11:104549411-104567977 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017100	protein coding gene	Chr11:94752246-94769342 (+)
CAST/EiJ	MGP_CASTEiJ_G0018384	protein coding gene	Chr11:101336569-101353330 (+)
CBA/J	MGP_CBAJ_G0018801	protein coding gene	Chr11:108903291-108936919 (+)
DBA/2J	MGP_DBA2J_G0018909	protein coding gene	Chr11:96754609-96772615 (+)
FVB/NJ	MGP_FVBNJ_G0018898	protein coding gene	Chr11:96267336-96284849 (+)
LP/J	MGP_LPJ_G0018979	protein coding gene	Chr11:101902818-101924973 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018925	protein coding gene	Chr11:108606914-108627370 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019508	protein coding gene	Chr11:100556602-100575508 (+)
PWK/PhJ	MGP_PWKPhJ_G0018155	protein coding gene	Chr11:97794494-97811871 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017944	protein coding gene	Chr11:100299954-100316513 (+)
WSB/EiJ	MGP_WSBEiJ_G0018433	protein coding gene	Chr11:100513562-100533731 (+)

Human Ortholog

RAPGEFL1, Rap guanine nucleotide exchange factor like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAPGEFL1, Rap guanine nucleotide exchange factor like 1
Synonyms

Link-GEFII
Links

HGNC:17428

NCBI Gene ID: 51195

UniProt: Q9UHV5
Chr Location

17q21.1; chr17:40177010-40195656 (+) GRCh38

MGI Vertebrate Homology

Rapgefl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAPGEFL1
Gene Tree

Rapgefl1

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Genomic Mutations

1 involving Rapgefl1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available

less

All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

29

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rapgefl1

less

All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS36303.1

Ensembl

ENSMUSG00000038020 (Evidence)
NCBI Gene

268480

			Length	Strain/Species	Flank
genomic	268480	NCBI Gene Model \| MGI Sequence Detail	16909	C57BL/6J	± kb
transcript	NM_001080925	RefSeq \| MGI Sequence Detail	4163	Not Specified
polypeptide	Q68EF8	UniProt \| EBI \| MGI Sequence Detail	662	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000013732 Rap guanine nucleotide exchange factor-like 1

(term hierarchy)
InterPro Domains

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR008937 Ras-like guanine nucleotide exchange factor

IPR029071 Ubiquitin-like domain superfamily

less

All nucleic 29

cDNA 29

Microarray probesets 1

Summaries

All 27

Gene Ontology 4

Phenotypes 9
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rapgefl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104802	Chr11:98727588-98727597 (+)	-18 bp
Tssr104803	Chr11:98727601-98727657 (+)	18 bp
Tssr104804	Chr11:98727662-98727685 (+)	63 bp
Tssr104805	Chr11:98727693-98727704 (+)	88 bp
Tssr104806	Chr11:98734624-98734626 (+)	7,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/09/2025 MGI 6.24