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Lingo3 Gene Detail
Summary
  • Symbol
    Lingo3
  • Name
    leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609246
    NCBI Gene: 237403
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80668635-80679873 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609246
protein coding gene Chr10:80668635-80679873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017523
protein coding gene Chr10:81494839-81506071 (-)
A/J MGP_AJ_G0017501
protein coding gene Chr10:78625044-78636275 (-)
AKR/J MGP_AKRJ_G0017462
protein coding gene Chr10:80779864-80791096 (-)
BALB/cJ MGP_BALBcJ_G0017463
protein coding gene Chr10:78841020-78852252 (-)
C3H/HeJ MGP_C3HHeJ_G0017286
protein coding gene Chr10:80865566-80876798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017917
protein coding gene Chr10:84290821-84302053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015606
protein coding gene Chr10:74836237-74847427 (-)
CAST/EiJ MGP_CASTEiJ_G0016853
protein coding gene Chr10:81098055-81109289 (-)
CBA/J MGP_CBAJ_G0017258
protein coding gene Chr10:87567894-87579126 (-)
DBA/2J MGP_DBA2J_G0017364
protein coding gene Chr10:77823405-77834637 (-)
FVB/NJ MGP_FVBNJ_G0017358
protein coding gene Chr10:77054481-77065713 (-)
LP/J MGP_LPJ_G0017435
protein coding gene Chr10:81954342-81965574 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017384
protein coding gene Chr10:89479775-89491007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017958
protein coding gene Chr10:80776001-80787233 (-)
PWK/PhJ MGP_PWKPhJ_G0016634
protein coding gene Chr10:77716278-77727568 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016424
protein coding gene Chr10:79724202-79735424 (-)
WSB/EiJ MGP_WSBEiJ_G0016913
protein coding gene Chr10:80810677-80821906 (-)



Homology
more
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2, LRRN6B
  • Links
    NCBI Gene ID: 645191
    neXtProt AC: NX_P0C6S8
    UniProt: P0C6S8

  • Chr Location
    19p13.3; chr19:2287164-2308154 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 237403 NCBI Gene Model | MGI Sequence Detail 11239 C57BL/6J ±  kb
transcript NM_001359746 RefSeq | MGI Sequence Detail 3478 C57BL/6  
polypeptide Q6GQU6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143690
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory