Tmem132b MGI Mouse Gene Detail - MGI:3609245

Symbol

Tmem132b
Name

transmembrane protein 132B

Feature Type

protein coding gene
IDs

MGI:3609245
NCBI Gene: 208151
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:125609449-125869647 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 64.27 cM
Mapping Data

1 experiment

SNPs within 2kb

1938 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3609245	protein coding gene	Chr5:125608838-125869647 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030114	protein coding gene	Chr5:129392007-129654287 (+)
A/J	MGP_AJ_G0030081	protein coding gene	Chr5:123966060-124222249 (+)
AKR/J	MGP_AKRJ_G0030015	protein coding gene	Chr5:127994384-128258841 (+)
BALB/cJ	MGP_BALBcJ_G0030091	protein coding gene	Chr5:125300385-125561835 (+)
C3H/HeJ	MGP_C3HHeJ_G0029808	protein coding gene	Chr5:128597234-128860101 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030544	protein coding gene	Chr5:134396582-134671003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027769	protein coding gene	Chr5:118498817-118753813 (+)
CAST/EiJ	MGP_CASTEiJ_G0029217	protein coding gene	Chr5:127740101-128004764 (+)
CBA/J	MGP_CBAJ_G0029778	protein coding gene	Chr5:139669972-139952277 (+)
DBA/2J	MGP_DBA2J_G0029928	protein coding gene	Chr5:123982101-124239222 (+)
FVB/NJ	MGP_FVBNJ_G0029884	protein coding gene	Chr5:123062943-123324973 (+)
LP/J	MGP_LPJ_G0030017	protein coding gene	Chr5:129906717-130179711 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029915	protein coding gene	Chr5:143173034-143436350 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030585	protein coding gene	Chr5:127605599-127873510 (+)
PWK/PhJ	MGP_PWKPhJ_G0028931	protein coding gene	Chr5:122821769-123084227 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028768	protein coding gene	Chr5:125246237-125512857 (+)
WSB/EiJ	MGP_WSBEiJ_G0029291	protein coding gene	Chr5:128308148-128570983 (+)

Human Ortholog

TMEM132B, transmembrane protein 132B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM132B, transmembrane protein 132B
Links

HGNC:29397

NCBI Gene ID: 114795

neXtProt AC: NX_Q14DG7

UniProt: Q14DG7
Chr Location

12q24.31-q24.32; chr12:125186386-125662377 (+) GRCh38

MGI Vertebrate Homology

Tmem132b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TMEM132B
Gene Tree

Tmem132b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

1
Genomic Mutations

2 involving Tmem132b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

8
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem132b

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS57384.1

Ensembl

ENSMUSG00000070498 (Evidence)
NCBI Gene

208151

			Length	Strain/Species	Flank
genomic	208151	NCBI Gene Model \| MGI Sequence Detail	260199	C57BL/6J	± kb
transcript	NM_001190352	RefSeq \| MGI Sequence Detail	7997	C57BL/6
polypeptide	NP_001177281	RefSeq \| MGI Sequence Detail	1078	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR026307 Transmembrane protein 132

IPR031437 Transmembrane protein family 132, middle domain

IPR031436 Transmembrane protein TMEM132, C-terminal

IPR031435 Transmembrane protein TMEM132, N-terminal

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 23

Developmental Gene Expression 1

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmem132b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48945	Chr5:125608851-125608883 (+)	-582 bp
Tssr48946	Chr5:125609441-125609457 (+)	0 bp
Tssr48947	Chr5:125609467-125609483 (+)	26 bp
Tssr1639	Chr5:125609595-125609602 (+)	150 bp
Tssr48948	Chr5:125609605-125609608 (+)	158 bp
Tssr48949	Chr5:125632501-125632503 (+)	23,053 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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