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Tmem145 Gene Detail
Summary
  • Symbol
    Tmem145
  • Name
    transmembrane protein 145
  • Synonyms
    B930076A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3607779
    NCBI Gene: 330485
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25005531-25015620 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3607779
protein coding gene Chr7:25004981-25015621 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031862
protein coding gene Chr7:23760991-23771988 (+)
A/J MGP_AJ_G0031841
protein coding gene Chr7:23152368-23162054 (+)
AKR/J MGP_AKRJ_G0031770
protein coding gene Chr7:23693805-23705990 (+)
BALB/cJ MGP_BALBcJ_G0031848
protein coding gene Chr7:23366025-23376079 (+)
C3H/HeJ MGP_C3HHeJ_G0031567
protein coding gene Chr7:24129250-24140333 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032310
protein coding gene Chr7:24556807-24567790 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029365
protein coding gene Chr7:24574037-24584474 (+)
CAST/EiJ MGP_CASTEiJ_G0030907
protein coding gene Chr7:17599075-17613396 (+)
CBA/J MGP_CBAJ_G0031532
protein coding gene Chr7:25473052-25482460 (+)
DBA/2J MGP_DBA2J_G0031686
protein coding gene Chr7:23054084-23065439 (+)
FVB/NJ MGP_FVBNJ_G0031639
protein coding gene Chr7:23055747-23065150 (+)
LP/J MGP_LPJ_G0031765
protein coding gene Chr7:24067248-24076933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031676
protein coding gene Chr7:25176379-25186289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032342
protein coding gene Chr7:23402406-23414009 (+)
PWK/PhJ MGP_PWKPhJ_G0030631
protein coding gene Chr7:17993498-18003350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030462
protein coding gene Chr7:14714932-14724753 (+)
WSB/EiJ MGP_WSBEiJ_G0031010
protein coding gene Chr7:23578613-23589754 (+)



Homology
more
  • Human Ortholog
    TMEM145, transmembrane protein 145
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM145, transmembrane protein 145
  • Links
    NCBI Gene ID: 284339
    neXtProt AC: NX_Q8NBT3
    UniProt: Q8NBT3

  • Chr Location
    19q13.2; chr19:42313309-42325064 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit progressive hearing impairment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043843 Ensembl Gene Model | MGI Sequence Detail 10090 C57BL/6J ±  kb
    transcript ENSMUST00000205639 Ensembl | MGI Sequence Detail 2789 Not Applicable  
    polypeptide ENSMUSP00000159059 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 1
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory