About   Help   FAQ
Firrm Gene Detail
Summary
  • Symbol
    Firrm
  • Name
    FIGNL1 interacting regulator of recombination and mitosis
  • Synonyms
    BC055324, FLIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:3590554
    NCBI Gene: 381306
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163773562-163822365 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 71.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3590554
protein coding gene Chr1:163773409-163822377 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016675
protein coding gene Chr1:169346633-169399405 (-)
A/J MGP_AJ_G0016656
protein coding gene Chr1:162452664-162502204 (-)
AKR/J MGP_AKRJ_G0016622
protein coding gene Chr1:167381381-167431613 (-)
BALB/cJ MGP_BALBcJ_G0016617
protein coding gene Chr1:162953952-163004277 (-)
C3H/HeJ MGP_C3HHeJ_G0016441
protein coding gene Chr1:167564568-167616891 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017078
protein coding gene Chr1:175052824-175105551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014787
protein coding gene Chr1:154426597-154478706 (-)
CAST/EiJ MGP_CASTEiJ_G0016021
protein coding gene Chr1:167192380-167246975 (-)
CBA/J MGP_CBAJ_G0016416
protein coding gene Chr1:181277738-181332554 (-)
DBA/2J MGP_DBA2J_G0016522
protein coding gene Chr1:161356417-161404799 (-)
FVB/NJ MGP_FVBNJ_G0016520
protein coding gene Chr1:159793570-159850207 (-)
LP/J MGP_LPJ_G0016593
protein coding gene Chr1:170435637-170487055 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016545
protein coding gene Chr1:188774012-188849512 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017114
protein coding gene Chr1:167207186-167258074 (-)
PWK/PhJ MGP_PWKPhJ_G0015807
protein coding gene Chr1:160543473-160593721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015594
protein coding gene Chr1:166088338-166136670 (-)
WSB/EiJ MGP_WSBEiJ_G0016083
protein coding gene Chr1:167371607-167425964 (-)



Homology
more
  • Human Ortholog
    FIRRM, FIGNL1 interacting regulator of recombination and mitosis
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIRRM, FIGNL1 interacting regulator of recombination and mitosis
  • Synonyms
    Apolo1, C1orf112, FLIP, MEICA1
  • Links
    NCBI Gene ID: 55732
    neXtProt AC: NX_Q9NSG2
    UniProt: Q9NSG2

  • Chr Location
    1q24.2; chr1:169662007-169854080 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041406 Ensembl Gene Model | MGI Sequence Detail 48804 C57BL/6J ±  kb
    transcript ENSMUST00000097493 Ensembl | MGI Sequence Detail 3217 Not Applicable  
    polypeptide ENSMUSP00000095101 Ensembl | MGI Sequence Detail 927 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:344887 Zhang Q, et al., The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. Nucleic Acids Res. 2023 Sep 8;51(16):8606-8622

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory