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Fbxw25 Gene Detail
Summary
  • Symbol
    Fbxw25
  • Name
    F-box and WD-40 domain protein 25
  • Synonyms
    E330001B16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588266
    NCBI Gene: 546160
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:109474190-109493720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    863 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588266
protein coding gene Chr9:109474082-109494415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035335
protein coding gene Chr9:111701662-111764514 (-)
A/J MGP_AJ_G0035316
protein coding gene Chr9:107646502-107676553 (-)
AKR/J MGP_AKRJ_G0035247
protein coding gene Chr9:110295832-110316071 (-)
BALB/cJ MGP_BALBcJ_G0035311
protein coding gene Chr9:107366451-107387740 (-)
C3H/HeJ MGP_C3HHeJ_G0035019
protein coding gene Chr9:110736650-110759221 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035831
protein coding gene Chr9:114726166-114757564 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0034986
protein coding gene Chr9:118935843-118959360 (-)
DBA/2J MGP_DBA2J_G0035145
protein coding gene Chr9:107090160-107112825 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0035223
protein coding gene Chr9:111975097-111999465 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035132
protein coding gene Chr9:120349450-120370594 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035851
protein coding gene Chr9:110632027-110652860 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Synonyms
    FBW12, FBXO12, FBXO35
  • Links
    NCBI Gene ID: 285231
    neXtProt AC: NX_Q6X9E4
    UniProt: Q6X9E4

  • Chr Location
    3p21.31; chr3:48372219-48401259 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000094992 Ensembl Gene Model | MGI Sequence Detail 19531 C57BL/6J ±  kb
    transcript ENSMUST00000163839 Ensembl | MGI Sequence Detail 1490 Not Applicable  
    polypeptide ENSMUSP00000128652 Ensembl | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2
    References
    more
    • Summaries
      All 14
      Gene Ontology 1
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory