Bex6 MGI Mouse Gene Detail - MGI:3588247 - brain expressed family member 6

Symbol

Bex6
Name

brain expressed family member 6
Synonyms

B020003O03Rik

Feature Type

protein coding gene
IDs

MGI:3588247
NCBI Gene: 328660
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:31998618-32005762 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 22.40 cM
Mapping Data

1 experiment

SNPs within 2kb

67 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588247	protein coding gene	Chr16:31998618-32005790 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022731	protein coding gene	Chr16:30230593-30231356 (+)
A/J	MGP_AJ_G0022696	protein coding gene	Chr16:28812415-28813178 (+)
AKR/J	MGP_AKRJ_G0022669	protein coding gene	Chr16:29861234-29861999 (+)
BALB/cJ	MGP_BALBcJ_G0022698	protein coding gene	Chr16:28964321-28965084 (+)
C3H/HeJ	MGP_C3HHeJ_G0022463	protein coding gene	Chr16:29987103-29987868 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023147	protein coding gene	Chr16:30873849-30874612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020665	protein coding gene	Chr16:29183840-29184618 (+)
CAST/EiJ	MGP_CASTEiJ_G0021991	protein coding gene	Chr16:30115457-30116223 (+)
CBA/J	MGP_CBAJ_G0022433	protein coding gene	Chr16:32123300-32124559 (+)
DBA/2J	MGP_DBA2J_G0022566	protein coding gene	Chr16:28667774-28668539 (+)
FVB/NJ	MGP_FVBNJ_G0022541	protein coding gene	Chr16:28647143-28647906 (+)
LP/J	MGP_LPJ_G0022633	protein coding gene	Chr16:30016243-30017008 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022560	protein coding gene	Chr16:31581800-31583030 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023159	protein coding gene	Chr16:29838636-29839399 (+)
PWK/PhJ	MGP_PWKPhJ_G0021730	protein coding gene	Chr16:28982665-28983431 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021561	protein coding gene	Chr16:29641086-29641841 (+)
WSB/EiJ	MGP_WSBEiJ_G0022035	protein coding gene	Chr16:29779045-29779811 (+)

Human Ortholog

BEX4, brain expressed X-linked 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BEX4, brain expressed X-linked 4
Synonyms

BEXL1
Links

HGNC:25475

NCBI Gene ID: 56271

neXtProt AC: NX_Q9NWD9

UniProt: Q9NWD9
Chr Location

Xq22.1; chrX:103215092-103217246 (+) GRCh38

MGI Vertebrate Homology

Bex6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BEX4
Protein SuperFamily

BEX
Gene Tree

Bex6

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Bex6
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

16
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS28116.1

Ensembl

ENSMUSG00000075269 (Evidence)
NCBI Gene

328660

			Length	Strain/Species	Flank
genomic	328660	NCBI Gene Model \| MGI Sequence Detail	7145	C57BL/6J	± kb
transcript	NM_001033539	RefSeq \| MGI Sequence Detail	983	C57BL/6
polypeptide	Q3TZW7	UniProt \| EBI \| MGI Sequence Detail	114	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004867 protein BEX6

(term hierarchy)
InterPro Domains

IPR007623 Brain-expressed X-linked protein

IPR021156 Transcription elongation factor A-like/Brain expressed X-linked

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All nucleic 7

cDNA 7

Microarray probesets 3

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:327759 Pollak RM, et al., Metabolic effects of the schizophrenia-associated 3q29 deletion. Transl Psychiatry. 2022 Feb 17;12(1):66

TSS for Bex6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137951	Chr16:31998594-31998606 (+)	-18 bp
Tssr137952	Chr16:31998612-31998653 (+)	15 bp
Tssr137953	Chr16:31998656-31998668 (+)	44 bp
Tssr137954	Chr16:31998672-31998675 (+)	56 bp
Tssr137955	Chr16:32002750-32002752 (+)	4,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23