About   Help   FAQ
Tmem253 Gene Detail
Summary
  • Symbol
    Tmem253
  • Name
    transmembrane protein 253
  • Synonyms
    G630016D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588246
    NCBI Gene: 619301
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52253115-52257251 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588246
 protein coding gene Chr14:52252309-52257251 (+)
129S1/SvImJ ENSMUSG00200016511
 protein coding gene Chr14:41052664-41057691 (+)
A/J ENSMUSG00195024550
 protein coding gene Chr14:41281864-41286891 (+)
AKR/J ENSMUSG00220032490
 protein coding gene Chr14:40637753-40642780 (+)
BALB/cJ ENSMUSG00180040830
 protein coding gene Chr14:40910826-40915855 (+)
C3H/HeJ ENSMUSG00175045418
 protein coding gene Chr14:42565001-42570028 (+)
C57BL/6NJ ENSMUSG00215026592
 protein coding gene Chr14:41262829-41268406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019233
 protein coding gene Chr14:44030611-44033523 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210035470
 protein coding gene Chr14:41264472-41269499 (+)
DBA/2J ENSMUSG00185051156
 protein coding gene Chr14:46177036-46182065 (+)
FVB/NJ ENSMUSG00205038859
 protein coding gene Chr14:40513412-40516306 (+)
JF1/MsJ ENSUMUG00000030099
 protein coding gene Chr14:58087900-58092966 (+)
LP/J ENSMUSG00230051983
 protein coding gene Chr14:58427278-58432305 (+)
NOD/ShiLtJ ENSMUSG00190034981
 protein coding gene Chr14:40947897-40950791 (+)
NZO/HlLtJ ENSMUSG00225048713
 protein coding gene Chr14:48725369-48730396 (+)
PWK/PhJ ENSLUMG00010038230
 protein coding gene Chr14:40477522-40482549 (+)
SPRET/EiJ ENSMSPG00010043006
 protein coding gene Chr14:44175431-44178391 (+)
WSB/EiJ ENSIUOG00005031128
 protein coding gene Chr14:40666819-40671848 (+)



Homology
more
  • Human Ortholog
    TMEM253, transmembrane protein 253
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM253, transmembrane protein 253
  • Synonyms
    C14orf176, C14orf95, NCRNA00220
  • Links
    NCBI Gene ID: 643382
    UniProt: P0C7T8

  • Chr Location
    14q11.2; chr14:21098811-21103724 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    28
  • Targeted
    1
  • Genomic Mutations
    1 involving Tmem253
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072571 Ensembl Gene Model | MGI Sequence Detail 4137 C57BL/6J ±  kb
transcript ENSMUST00000100638 Ensembl | MGI Sequence Detail 1234 Not Applicable  
polypeptide ENSMUSP00000098203 Ensembl | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Gene Ontology 1
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory