Rufy4 MGI Mouse Gene Detail - MGI:3588214 - RUN and FYVE domain containing 4

Symbol

Rufy4
Name

RUN and FYVE domain containing 4
Synonyms

F930048N03Rik

Feature Type

protein coding gene
IDs

MGI:3588214
NCBI Gene: 435626
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:74164700-74187382 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.38 cM
Mapping Data

1 experiment

SNPs within 2kb

835 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588214	protein coding gene	Chr1:74163768-74187389 (+)
129S1/SvImJ	ENSMUSG00200034493	protein coding gene	Chr1:71827792-71850493 (+)
A/J	ENSMUSG00195009871	protein coding gene	Chr1:71253020-71275693 (+)
AKR/J	ENSMUSG00220010132	protein coding gene	Chr1:71398331-71420978 (+)
BALB/cJ	ENSMUSG00180015781	protein coding gene	Chr1:71511351-71534037 (+)
C3H/HeJ	ENSMUSG00175017043	protein coding gene	Chr1:71653439-71676110 (+)
C57BL/6NJ	ENSMUSG00215011601	protein coding gene	Chr1:71556671-71579360 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014252	protein coding gene	Chr1:67671005-67693159 (+)
CAST/EiJ	ENSTCUG00005026375	protein coding gene	Chr1:71282649-71305293 (+)
CBA/J	ENSMUSG00210035036	protein coding gene	Chr1:71337709-71360378 (+)
DBA/2J	ENSMUSG00185028322	protein coding gene	Chr1:72431005-72453656 (+)
FVB/NJ	ENSMUSG00205025410	protein coding gene	Chr1:71006290-71028986 (+)
JF1/MsJ	ENSUMUG00000005618	protein coding gene	Chr1:71327734-71350530 (+)
LP/J	ENSMUSG00230009044	protein coding gene	Chr1:72421010-72443691 (+)
NOD/ShiLtJ	ENSMUSG00190035928	protein coding gene	Chr1:71564268-71586713 (+)
NZO/HlLtJ	ENSMUSG00225039583	protein coding gene	Chr1:75636124-75658812 (+)
PWK/PhJ	ENSLUMG00010012404	protein coding gene	Chr1:70905211-70928038 (+)
SPRET/EiJ	ENSMSPG00010019323	protein coding gene	Chr1:73006350-73029121 (+)
WSB/EiJ	ENSIUOG00005012182	protein coding gene	Chr1:71185222-71207913 (+)

Human Ortholog

RUFY4, RUN and FYVE domain containing 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RUFY4, RUN and FYVE domain containing 4
Synonyms

ZFYVE31
Links

HGNC:24804

NCBI Gene ID: 285180

UniProt: Q6ZNE9
Chr Location

2q35; chr2:218034934-218090652 (+) GRCh38

MGI Vertebrate Homology

Rufy4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RUFY4
Gene Tree

Rufy4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Genomic Mutations

2 involving Rufy4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

110 strains or lines available

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All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

604
Tissues

5
cDNA Data

5
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

20
UniProt

1
CCDS

CCDS15039.1, CCDS48289.1

Ensembl

ENSMUSG00000061815 (Evidence)
NCBI Gene

435626

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061815	Ensembl Gene Model \| MGI Sequence Detail	22683	C57BL/6J	± kb
transcript	ENSMUST00000127134	Ensembl \| MGI Sequence Detail	1841	Not Applicable
polypeptide	ENSMUSP00000115873	Ensembl \| MGI Sequence Detail	563	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031545 RUN and FYVE domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR059036 RUFY4-like domain

IPR042939 RUN and FYVE domain-containing protein 4

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR011011 Zinc finger, FYVE/PHD-type

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 7

cDNA 5

Primer pair 2

Antibodies 1

Microarray probesets 1

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354513 Kim M, et al., RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts. Bone Res. 2024 May 15;12(1):29

TSS for Rufy4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7353	Chr1:74164694-74164727 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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