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Rtl4 Gene Detail
Summary
  • Symbol
    Rtl4
  • Name
    retrotransposon Gag like 4
  • Synonyms
    C230031A03Rik, Mar4, Zcchc16
Location &
Maps
more
  • Sequence Map
    ChrX:143471903-143905407 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 65.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9519 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588192
 protein coding gene ChrX:143471147-143905410 (+)
129S1/SvImJ ENSMUSG00200028814
 protein coding gene ChrX:122487129-122920659 (+)
A/J ENSMUSG00195018568
 protein coding gene ChrX:126321446-126735703 (+)
AKR/J ENSMUSG00220034846
 protein coding gene ChrX:119672704-120104348 (+)
BALB/cJ ENSMUSG00180036709
 protein coding gene ChrX:122743934-123175651 (+)
C3H/HeJ ENSMUSG00175026084
 protein coding gene ChrX:126646030-127079571 (+)
C57BL/6NJ ENSMUSG00215018684
 protein coding gene ChrX:123253411-123686954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033475
 protein coding gene ChrX:133494571-133514685 (+)
CAST/EiJ ENSTCUG00005032578
 protein coding gene ChrX:123819847-124234594 (+)
CBA/J ENSMUSG00210029514
 protein coding gene ChrX:123569872-124003403 (+)
DBA/2J ENSMUSG00185032785
 protein coding gene ChrX:137460782-137894341 (+)
FVB/NJ ENSMUSG00205024825
 protein coding gene ChrX:121948282-122375722 (+)
JF1/MsJ ENSUMUG00000019039
 protein coding gene ChrX:156692261-157121589 (+)
LP/J ENSMUSG00230031984
 protein coding gene ChrX:144073152-144506663 (+)
NOD/ShiLtJ ENSMUSG00190033040
 protein coding gene ChrX:122949733-123381790 (+)
NZO/HlLtJ ENSMUSG00225041996
 protein coding gene ChrX:148793191-149208880 (+)
PWK/PhJ ENSLUMG00010040314
 protein coding gene ChrX:121379649-121793127 (+)
SPRET/EiJ ENSMSPG00010036531
 protein coding gene ChrX:126584978-126588044 (+)
WSB/EiJ ENSIUOG00005036127
 protein coding gene ChrX:123594783-124039900 (+)



Homology
more
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
  • Synonyms
    Mar4, Mart4, SIRH1, SIRH11, ZCCHC16
  • Links
    NCBI Gene ID: 340595
    UniProt: Q6ZR62

  • Chr Location
    Xq23; chrX:112082965-112458566 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal behavior including hyperactivity and abnormal responses to a new environment, and abnormal working memory and cognition. Neuronal norepinephrine levesl are slow to recover after induced neurotransmitter release. Mortality, growth, kidney function, and reproductive system biology are all unaffected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    28
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071679 Ensembl Gene Model | MGI Sequence Detail 433505 C57BL/6J ±  kb
transcript ENSMUST00000096301 Ensembl | MGI Sequence Detail 1758 Not Applicable  
polypeptide ENSMUSP00000108463 Ensembl | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:5906148
References
more
  • Summaries
    All 24
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:96508 Brandt J, et al., Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005 Jan 17;345(1):101-11
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory