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Cdkl4 Gene Detail
Summary
  • Symbol
    Cdkl4
  • Name
    cyclin dependent kinase like 4
  • Synonyms
    LOC381113
  • Feature Type
    protein coding gene
  • IDs
    MGI:3587025
    NCBI Gene: 381113
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80830979-80885242 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3587025
 protein coding gene Chr17:80830979-80885242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024065
 protein coding gene Chr17:83454382-83493315 (-)
A/J MGP_AJ_G0024022
 protein coding gene Chr17:80900065-80955934 (-)
AKR/J MGP_AKRJ_G0023991
 protein coding gene Chr17:82173131-82213934 (-)
BALB/cJ MGP_BALBcJ_G0024024
 protein coding gene Chr17:80763703-80806114 (-)
C3H/HeJ MGP_C3HHeJ_G0023788
 protein coding gene Chr17:83030545-83072025 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024468
 protein coding gene Chr17:86487548-86531419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021909
 protein coding gene Chr17:76244059-76296287 (-)
CAST/EiJ MGP_CASTEiJ_G0023268
 protein coding gene Chr17:83714919-83760798 (-)
CBA/J MGP_CBAJ_G0023762
 protein coding gene Chr17:90107224-90155808 (-)
DBA/2J MGP_DBA2J_G0023891
 protein coding gene Chr17:79389663-79430478 (-)
FVB/NJ MGP_FVBNJ_G0023857
 protein coding gene Chr17:78887893-78928939 (-)
LP/J MGP_LPJ_G0023974
 protein coding gene Chr17:84285910-84343512 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0024513
 protein coding gene Chr17:82646568-82692584 (-)
PWK/PhJ MGP_PWKPhJ_G0023014
 protein coding gene Chr17:78945302-78987782 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022825
 protein coding gene Chr17:79435607-79479972 (-)
WSB/EiJ MGP_WSBEiJ_G0023335
 protein coding gene Chr17:83466878-83516283 (-)



Homology
more
  • Human Ortholog
    CDKL4, cyclin dependent kinase like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKL4, cyclin dependent kinase like 4
  • Links
    NCBI Gene ID: 344387
    neXtProt AC: NX_Q5MAI5
    UniProt: Q5MAI5

  • Chr Location
    2p22.1; chr2:39168045-39247120 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    35
  • cDNA Data
    14
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381113 NCBI Gene Model | MGI Sequence Detail 54264 C57BL/6J ±  kb
transcript NM_001360144 RefSeq | MGI Sequence Detail 3078 C57BL/6  
polypeptide Q3TZA2 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147007, MGI:2685788
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/21/2023
MGI 6.22 		The Jackson Laboratory