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Nlrp1b Gene Detail
Summary
  • Symbol
    Nlrp1b
  • Name
    NLR family, pyrin domain containing 1B
  • Synonyms
    Nalp1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3582959
    NCBI Gene: 637515
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:71043928-71121559 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1654 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3582959
 protein coding gene Chr11:71043400-71133340 (-)
129S1/SvImJ no annotation
A/J ENSMUSG00195051920
 protein coding gene Chr11:68017697-68095698 (-)
AKR/J ENSMUSG00220054059
 protein coding gene Chr11:68141797-68176654 (-)
BALB/cJ ENSMUSG00180051990
 protein coding gene Chr11:68080864-68113821 (-)
C3H/HeJ ENSMUSG00175041842
 protein coding gene Chr11:68028172-68061123 (-)
C57BL/6NJ ENSMUSG00215049609
 protein coding gene Chr11:67813484-67891486 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005053577
 protein coding gene Chr11:67570084-67621297 (-)
CBA/J ENSMUSG00210051037
 protein coding gene Chr11:67882256-67915211 (-)
DBA/2J ENSMUSG00185054666
 protein coding gene Chr11:68114898-68163799 (-)
FVB/NJ ENSMUSG00205052167
 protein coding gene Chr11:67975517-68008484 (-)
JF1/MsJ ENSUMUG00000056951
 protein coding gene Chr11:68513529-68562464 (-)
LP/J ENSMUSG00230052819
 protein coding gene Chr11:69193442-69226391 (-)
NOD/ShiLtJ ENSMUSG00190035081
 protein coding gene Chr11:68130872-68165726 (-)
NZO/HlLtJ ENSMUSG00225039119
 protein coding gene Chr11:71374647-71407587 (-)
PWK/PhJ ENSLUMG00010053375
 protein coding gene Chr11:68013609-68064566 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOGG00005054459
 protein coding gene Chr11:68014448-68069891 (-)



Homology
more
  • Human Ortholog
    NLRP1, NLR family pyrin domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP1, NLR family pyrin domain containing 1
  • Synonyms
    AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, JRRP, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1
  • Links
    NCBI Gene ID: 22861
    UniProt: Q9C000

  • Chr Location
    17p13.2; chr17:5499415-5619424 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NLRP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070390 Ensembl Gene Model | MGI Sequence Detail 77632 C57BL/6J ±  kb
transcript ENSMUST00000108515 Ensembl | MGI Sequence Detail 4131 Not Applicable  
polypeptide ENSMUSP00000104155 Ensembl | MGI Sequence Detail 1177 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:3641853, MGI:3712674
References
more
  • Summaries
    All 70
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 44
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:387239 Mazzone RJ, et al., NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells. Microbes Infect. 2024 Nov-Dec;26(8):105398
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory