Tor1aip2 MGI Mouse Gene Detail - MGI:3582695 - torsin A interacting protein 2

Symbol

Tor1aip2
Name

torsin A interacting protein 2
Synonyms

1110020D10Rik, 15kDa, Ifrg15, LULL1

Feature Type

protein coding gene
IDs

MGI:3582695
NCBI Gene: 240832
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:155911410-155944607 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.70 cM, cytoband G3
Mapping Data

4 experiments

SNPs within 2kb

844 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3582695	protein coding gene	Chr1:155911149-155944607 (+)
129S1/SvImJ	ENSMUSG00200005877	protein coding gene	Chr1:153353078-153386536 (+)
129S1/SvImJ	ENSMUSG00200005864	protein coding gene	Chr1:153338164-153374435 (+)
A/J	ENSMUSG00195022003	protein coding gene	Chr1:152763633-152773599 (+)
A/J	ENSMUSG00195022053	protein coding gene	Chr1:152739870-152757986 (+)
AKR/J	ENSMUSG00220004870	protein coding gene	Chr1:152562909-152572879 (+)
AKR/J	ENSMUSG00220004894	protein coding gene	Chr1:152539146-152557262 (+)
BALB/cJ	ENSMUSG00180031111	protein coding gene	Chr1:152959040-152977157 (+)
BALB/cJ	ENSMUSG00180031055	protein coding gene	Chr1:152982804-152992772 (+)
C3H/HeJ	ENSMUSG00175002782	protein coding gene	Chr1:153003445-153021561 (+)
C3H/HeJ	ENSMUSG00175002773	protein coding gene	Chr1:153027208-153037176 (+)
C57BL/6NJ	ENSMUSG00215003580	protein coding gene	Chr1:152882364-152919188 (+)
C57BL/6NJ	ENSMUSG00215003600	protein coding gene	Chr1:152897284-152930742 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014731	protein coding gene	Chr1:146750296-146784047 (+)
CAST/EiJ	ENSTCUG00005005498	protein coding gene	Chr1:151577175-151587043 (+)
CBA/J	ENSMUSG00210033942	protein coding gene	Chr1:152901555-152919671 (+)
CBA/J	ENSMUSG00210033822	protein coding gene	Chr1:152925318-152935288 (+)
DBA/2J	ENSMUSG00185040341	protein coding gene	Chr1:157202010-157211978 (+)
DBA/2J	ENSMUSG00185040394	protein coding gene	Chr1:157178247-157196363 (+)
FVB/NJ	ENSMUSG00205024542	protein coding gene	Chr1:152033940-152052057 (+)
FVB/NJ	ENSMUSG00205024219	protein coding gene	Chr1:152057704-152067674 (+)
JF1/MsJ	ENSUMUG00000007744	protein coding gene	Chr1:156353987-156363951 (+)
LP/J	ENSMUSG00230015839	protein coding gene	Chr1:156728116-156764939 (+)
LP/J	ENSMUSG00230015884	protein coding gene	Chr1:156743034-156776492 (+)
NOD/ShiLtJ	ENSMUSG00190011688	protein coding gene	Chr1:152773450-152783417 (+)
NOD/ShiLtJ	ENSMUSG00190011716	protein coding gene	Chr1:152749688-152767803 (+)
NZO/HlLtJ	ENSMUSG00225005861	protein coding gene	Chr1:160399642-160436457 (+)
NZO/HlLtJ	ENSMUSG00225005883	protein coding gene	Chr1:160414553-160448010 (+)
PWK/PhJ	ENSLUMG00010027796	protein coding gene	Chr1:151712778-151722764 (+)
SPRET/EiJ	ENSMSPG00010035432	protein coding gene	Chr1:155041335-155074845 (+)
WSB/EiJ	ENSIUOG00005023200	protein coding gene	Chr1:152331595-152365054 (+)

Human Ortholog

TOR1AIP2, torsin 1A interacting protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOR1AIP2, torsin 1A interacting protein 2
Synonyms

IFRG15, LULL1, NET9
Links

HGNC:24055

NCBI Gene ID: 163590

UniProt: Q8NFQ8, Q9H496
Chr Location

1q25.2; chr1:179839967-179883034 (-) GRCh38

MGI Vertebrate Homology

Tor1aip2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TOR1AIP2
Gene Tree

Tor1aip2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

All Mutations and Alleles

74
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

66
Targeted

5
Genomic Mutations

2 involving Tor1aip2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

94 strains or lines available

Mice with loss of expression in the liver are viable and do not develop hepatic steatosis.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

678
Tissues

52
cDNA Data

32
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tor1aip2

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All Sequences

135
RefSeq

34
UniProt

4
CCDS

CCDS15388.1, CCDS15389.1

Ensembl

ENSMUSG00000050565 (Evidence)
NCBI Gene

240832

			Length	Strain/Species	Flank
genomic	240832	NCBI Gene Model \| MGI Sequence Detail	33198	C57BL/6J	± kb
transcript	NM_172843	RefSeq \| MGI Sequence Detail	5857	C57BL/6
polypeptide	Q8BYU6	UniProt \| EBI \| MGI Sequence Detail	502	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016552 torsin-1A-interacting protein 2

(term hierarchy)
InterPro Domains

IPR038599 LAP1C-like, C-terminal domain superfamily

IPR008662 Torsin-1A-interacting protein 1/2

IPR046753 Torsin-1A-interacting protein 1/2, AAA+ activator domain

IPR046754 Torsin-1A-interacting protein 1/2, N-terminal
GlyGen

Q8BYU6 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

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All nucleic 36

cDNA 34

Primer pair 1

Other 1

Antibodies 1

Microarray probesets 11

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MGI:1915073, MGI:1929890, MGI:2138554, MGI:2138622, MGI:2138663, MGI:3034941

Summaries

All 55

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345574 Hernandez-Ono A, et al., Dynamic regulation of hepatic lipid metabolism by torsinA and its activators. JCI Insight. 2024 Jan 9;:e175328

TSS for Tor1aip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9544	Chr1:155911138-155911177 (+)	-252 bp
Tssr9545	Chr1:155911451-155911509 (+)	70 bp
Tssr9546	Chr1:155911521-155911534 (+)	118 bp
Tssr9547	Chr1:155911934-155912004 (+)	559 bp
Tssr9548	Chr1:155916630-155916644 (+)	5,227 bp
Tssr9549	Chr1:155916655-155916671 (+)	5,253 bp
Tssr9550	Chr1:155916826-155916854 (+)	5,430 bp
Tssr9551	Chr1:155919997-155919998 (+)	8,588 bp
Tssr9552	Chr1:155927132-155927139 (+)	15,726 bp
Tssr9553	Chr1:155927179-155927200 (+)	15,780 bp
Tssr9554	Chr1:155928045-155928059 (+)	16,642 bp
Tssr9555	Chr1:155928194-155928220 (+)	16,797 bp
Tssr9556	Chr1:155943214-155943219 (+)	31,807 bp
Tssr9557	Chr1:155943577-155943580 (+)	32,169 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24