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Klf14 Gene Detail
Summary
  • Symbol
    Klf14
  • Name
    Kruppel-like transcription factor 14
  • Synonyms
    5330411L03Rik, BTEB5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3577024
    NCBI Gene: 619665
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30932956-30935925 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3577024
 protein coding gene Chr6:30932956-30936013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030547
 protein coding gene Chr6:28855775-28858823 (-)
A/J MGP_AJ_G0030520
 protein coding gene Chr6:27639887-27642944 (-)
AKR/J MGP_AKRJ_G0030447
 protein coding gene Chr6:28564945-28568000 (-)
BALB/cJ MGP_BALBcJ_G0030530
 protein coding gene Chr6:27759902-27762951 (-)
C3H/HeJ MGP_C3HHeJ_G0030243
 protein coding gene Chr6:28569296-28572350 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030984
 protein coding gene Chr6:29677083-29680133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028195
 protein coding gene Chr6:25802412-25805471 (-)
CAST/EiJ MGP_CASTEiJ_G0029645
 protein coding gene Chr6:28346119-28349168 (-)
CBA/J MGP_CBAJ_G0030221
 protein coding gene Chr6:30852795-30855848 (-)
DBA/2J MGP_DBA2J_G0030365
 protein coding gene Chr6:27538886-27541936 (-)
FVB/NJ MGP_FVBNJ_G0030319
 protein coding gene Chr6:27331441-27334491 (-)
LP/J MGP_LPJ_G0030452
 protein coding gene Chr6:29043400-29046456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030355
 protein coding gene Chr6:33245604-33248649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031014
 protein coding gene Chr6:28452406-28455460 (-)
PWK/PhJ MGP_PWKPhJ_G0029359
 protein coding gene Chr6:27118723-27121772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029195
 protein coding gene Chr6:28147571-28150617 (-)
WSB/EiJ MGP_WSBEiJ_G0029721
 protein coding gene Chr6:28381544-28384597 (-)



Homology
more
  • Human Ortholog
    KLF14, KLF transcription factor 14
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF14, KLF transcription factor 14
  • Synonyms
    BTEB5
  • Links
    NCBI Gene ID: 136259
    neXtProt AC: NX_Q8TD94
    UniProt: Q8TD94

  • Chr Location
    7q32.2; chr7:130730697-130734207 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display genome instability and increased tumor incidence with age. Mice homozygous for a conditional allele knocked out in the liver exhibit decreased circulating HDL cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    30
  • cDNA Data
    3
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 619665 NCBI Gene Model | MGI Sequence Detail 2970 C57BL/6J ±  kb
    transcript NM_001135093 RefSeq | MGI Sequence Detail 2970 C57BL/6  
    polypeptide Q19A41 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141528
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:334391 Chen L, et al., Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation. Free Radic Biol Med. 2022 Dec 28;195:132-144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory