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Greb1l Gene Detail
Summary
  • Symbol
    Greb1l
  • Name
    growth regulation by estrogen in breast cancer-like
  • Synonyms
    AK220484, mKIAA4095
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576497
    NCBI Gene: 381157
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:10325177-10562940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 5.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1241 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576497
 protein coding gene Chr18:10324933-10562945 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024147
 protein coding gene Chr18:7257752-7503940 (+)
A/J MGP_AJ_G0024109
 protein coding gene Chr18:7208554-7455576 (+)
AKR/J MGP_AKRJ_G0024076
 protein coding gene Chr18:7400117-7642255 (+)
BALB/cJ MGP_BALBcJ_G0024108
 protein coding gene Chr18:7196301-7437295 (+)
C3H/HeJ MGP_C3HHeJ_G0023875
 protein coding gene Chr18:7287374-7542653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024553
 protein coding gene Chr18:7691730-7948482 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021992
 protein coding gene Chr18:6880299-7112056 (+)
CAST/EiJ MGP_CASTEiJ_G0023352
 protein coding gene Chr18:7192956-7435116 (+)
CBA/J MGP_CBAJ_G0023847
 protein coding gene Chr18:7743298-7998316 (+)
DBA/2J MGP_DBA2J_G0023976
 protein coding gene Chr18:7075527-7316391 (+)
FVB/NJ MGP_FVBNJ_G0023941
 protein coding gene Chr18:7025913-7261133 (+)
LP/J MGP_LPJ_G0024059
 protein coding gene Chr18:7384051-7631180 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023970
 protein coding gene Chr18:7993450-8247094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024599
 protein coding gene Chr18:7230919-7474957 (+)
PWK/PhJ MGP_PWKPhJ_G0023098
 protein coding gene Chr18:7114541-7359539 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022908
 protein coding gene Chr18:7522036-7742523 (+)
WSB/EiJ MGP_WSBEiJ_G0023418
 protein coding gene Chr18:7210229-7450202 (+)



Homology
more
  • Human Ortholog
    GREB1L, GREB1 like retinoic acid receptor coactivator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GREB1L, GREB1 like retinoic acid receptor coactivator
  • Synonyms
    C18orf6, DFNA80, KIAA1772, RHDA3
  • Links
    NCBI Gene ID: 80000
    neXtProt AC: NX_Q9C091
    UniProt: Q9C091

  • Chr Location
    18q11.1-q11.2; chr18:21242232-21526112 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GREB1L associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality, decreased embryo size, bilateral kidney agenesis, absence of Wolffian and Mullerian ducts, small testis, heart defects, and exencephaly. Heterozygotes display a slight decrease in ureteric bud branching morphogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    18
  • cDNA Data
    23
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042942 Ensembl Gene Model | MGI Sequence Detail 237764 C57BL/6J ±  kb
    transcript ENSMUST00000048977 Ensembl | MGI Sequence Detail 8420 Not Applicable  
    polypeptide ENSMUSP00000049003 Ensembl | MGI Sequence Detail 1913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:341993 Bernheim S, et al., Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells. Dev Cell. 2023 Oct 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory