AK157302 MGI Mouse Gene Detail - MGI:3574096

AK157302 Gene Detail

Symbol

AK157302
Name

cDNA sequence AK157302

Feature Type

protein coding gene

BioType Conflict
IDs

MGI:3574096
NCBI Gene: 432732
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:21679393-21681307 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 7.83 cM
Mapping Data

1 experiment

SNPs within 2kb

12 from dbSNP Build 142
Strain Annotations

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3574096	protein coding gene	Chr13:21679393-21681316 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020280	protein coding gene	Chr13:18762486-18767037 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0020212	protein coding gene	Chr13:18659873-18662676 (+)
BALB/cJ	MGP_BALBcJ_G0020224	protein coding gene	Chr13:18406482-18408405 (+)
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0022135	protein coding gene	Chr16:52838644-52841176 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0020181	protein coding gene	Chr13:19011795-19014242 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

ISCA1, iron-sulfur cluster assembly 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISCA1, iron-sulfur cluster assembly 1
Synonyms

HBLD2, hIscA, hIscA1, ISA1, MMDS5
Links

HGNC:28660

NCBI Gene ID: 81689

neXtProt AC: NX_Q9BUE6

UniProt: Q9BUE6
Chr Location

9q21.33; chr9:86264546-86283102 (-) GRCh38

MGI Vertebrate Homology

AK157302 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ISCA1
Gene Tree

AK157302

Diseases

1 with human ISCA1 associations

				Human Disease	Mouse Models
				multiple mitochondrial dysfunctions syndrome 5 IDs multiple mitochondrial dysfunctions syndrome 5 DOID:0080274 OMIM:617613

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving AK157302
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

Expression Atlas

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All Sequences

13
RefSeq

2
UniProt

1

Ensembl

ENSMUSG00000078139 (Evidence)
NCBI Gene

432732

Representative Sequences				Length	Strain/Species	Flank
	genomic	432732	NCBI Gene Model \| MGI Sequence Detail	1915	C57BL/6J	± kb
	polypeptide	I3ITR1	UniProt \| EBI \| MGI Sequence Detail	129	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR000361 FeS cluster biogenesis

IPR017870 FeS cluster insertion, C-terminal, conserved site

IPR016092 FeS cluster insertion protein

IPR035903 HesB-like domain superfamily

Summaries

All 16

Gene Ontology 2

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

TSS for AK157302:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118782	Chr13:21679388-21679430 (+)	16 bp
Tssr118783	Chr13:21679527-21679551 (+)	146 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23