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Crocc Gene Detail
Summary
  • Symbol
    Crocc
  • Name
    ciliary rootlet coiled-coil, rootletin
  • Feature Type
    protein coding gene
  • IDs
    MGI:3529431
    NCBI Gene: 230872
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140743948-140787861 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 73.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1560 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3529431
 protein coding gene Chr4:140743948-140787927 (-)
129S1/SvImJ ENSMUSG00200043564
 protein coding gene Chr4:134160629-134198726 (-)
A/J ENSMUSG00195031492
 protein coding gene Chr4:135509417-135554048 (-)
AKR/J ENSMUSG00220041105
 protein coding gene Chr4:134510214-134547914 (-)
BALB/cJ ENSMUSG00180044877
 protein coding gene Chr4:133150573-133195205 (-)
C3H/HeJ ENSMUSG00175034545
 protein coding gene Chr4:134177084-134221716 (-)
C57BL/6NJ ENSMUSG00215048324
 protein coding gene Chr4:135694960-135732659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026731
 protein coding gene Chr4:130691007-130735955 (-)
CAST/EiJ ENSTCUG00005013499
 protein coding gene Chr4:135133701-135171347 (-)
CBA/J ENSMUSG00210028986
 protein coding gene Chr4:133801068-133838758 (-)
DBA/2J ENSMUSG00185050669
 protein coding gene Chr4:135312778-135357854 (-)
FVB/NJ ENSMUSG00205040985
 protein coding gene Chr4:133565587-133603735 (-)
JF1/MsJ ENSUMUG00000038925
 protein coding gene Chr4:136002753-136040454 (-)
LP/J ENSMUSG00230033820
 protein coding gene Chr4:139099173-139137271 (-)
NOD/ShiLtJ ENSMUSG00190022645
 protein coding gene Chr4:133559398-133604479 (-)
NZO/HlLtJ ENSMUSG00225008212
 protein coding gene Chr4:145051052-145096131 (-)
PWK/PhJ ENSLUMG00010036465
 protein coding gene Chr4:132998196-133043272 (-)
SPRET/EiJ ENSMSPG00010029204
 protein coding gene Chr4:135047069-135088716 (-)
WSB/EiJ ENSIUOG00005038356
 protein coding gene Chr4:133447601-133492460 (-)



Homology
more
  • Human Ortholog
    CROCC, ciliary rootlet coiled-coil, rootletin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CROCC, ciliary rootlet coiled-coil, rootletin
  • Synonyms
    CROCC1, ROLT, TAX1BP2
  • Links
    NCBI Gene ID: 9696
    UniProt: Q5TZA2

  • Chr Location
    1p36.13; chr1:16740273-16972964 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show no apparent functional deficits in phototransduction and ciliary beating in sensory and motile cilia. However, photoreceptors degenerate over time, and lungs appear prone to pathological changes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    32
  • cDNA Data
    50
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040860 Ensembl Gene Model | MGI Sequence Detail 43914 C57BL/6J ±  kb
    transcript ENSMUST00000102491 Ensembl | MGI Sequence Detail 6582 Not Applicable  
    polypeptide ENSMUSP00000099549 Ensembl | MGI Sequence Detail 2009 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50
      Antibodies 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 16
    • Earliest
      J:80161 Yang J, et al., Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. J Cell Biol. 2002 Nov 11;159(3):431-40
    • Latest
      J:332376 Van Heurck R, et al., CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. Neuron. 2023 Jan 4;111(1):65-80.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory