A4galt MGI Mouse Gene Detail - MGI:3512453 - alpha 1,4-galactosyltransferase

Symbol

A4galt
Name

alpha 1,4-galactosyltransferase
Synonyms

Gb3 synthase

Feature Type

protein coding gene
IDs

MGI:3512453
NCBI Gene: 239559
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:83110923-83135930 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.40 cM
Mapping Data

1 experiment

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3512453	protein coding gene	Chr15:83110923-83135975 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022161	protein coding gene	Chr15:83896236-83931806 (-)
A/J	MGP_AJ_G0022120	protein coding gene	Chr15:80838391-80863675 (-)
AKR/J	MGP_AKRJ_G0022095	protein coding gene	Chr15:83160058-83203229 (-)
BALB/cJ	MGP_BALBcJ_G0022126	protein coding gene	Chr15:80981965-81010441 (-)
C3H/HeJ	MGP_C3HHeJ_G0021896	protein coding gene	Chr15:83154074-83181429 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022571	protein coding gene	Chr15:87139262-87174142 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020095	protein coding gene	Chr15:77216924-77244226 (-)
CAST/EiJ	MGP_CASTEiJ_G0021418	protein coding gene	Chr15:83904875-83941617 (-)
CBA/J	MGP_CBAJ_G0021863	protein coding gene	Chr15:89887832-89917427 (-)
DBA/2J	MGP_DBA2J_G0021990	protein coding gene	Chr15:80328690-80353268 (-)
FVB/NJ	MGP_FVBNJ_G0021969	protein coding gene	Chr15:79369916-79395143 (-)
LP/J	MGP_LPJ_G0022061	protein coding gene	Chr15:84072294-84099324 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021989	protein coding gene	Chr15:94815954-94846255 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022586	protein coding gene	Chr15:83201035-83227013 (-)
PWK/PhJ	MGP_PWKPhJ_G0021159	protein coding gene	Chr15:80301851-80330710 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020993	protein coding gene	Chr15:82910469-82941309 (-)
WSB/EiJ	MGP_WSBEiJ_G0021467	protein coding gene	Chr15:83689090-83715923 (-)

Human Ortholog

A4GALT, alpha 1,4-galactosyltransferase (P1PK blood group)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

A4GALT, alpha 1,4-galactosyltransferase (P1PK blood group)
Synonyms

A14GALT, A4GALT1, Gb3S, P1, P1PK, P(k), PK
Links

HGNC:18149

NCBI Gene ID: 53947

neXtProt AC: NX_Q9NPC4

UniProt: Q9NPC4
Chr Location

22q13.2; chr22:42692121-42721301 (-) GRCh38

MGI Vertebrate Homology

A4galt stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: A4GALT
Gene Tree

A4galt

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

112
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

101
Radiation induced

2
Targeted

6
Genomic Mutations

3 involving A4galt
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

Homozygous null mice display reduced sensitivity to verotoxin but do not display any gross morphological abnormalities.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

28
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

52
RefSeq

10
UniProt

5
CCDS

CCDS27699.1

Ensembl

ENSMUSG00000047878 (Evidence)
NCBI Gene

239559

			Length	Strain/Species	Flank
genomic	239559	NCBI Gene Model \| MGI Sequence Detail	25008	C57BL/6J	± kb
transcript	NM_001416098	RefSeq \| MGI Sequence Detail	2261	C57BL/6
polypeptide	Q67BJ4	UniProt \| EBI \| MGI Sequence Detail	359	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003516 lactosylceramide 4-alpha-galactosyltransferase

(term hierarchy)
EC

2.4.1.228
InterPro Domains

IPR007652 Alpha 1,4-glycosyltransferase domain

IPR007577 Glycosyltransferase, DXD sugar-binding motif

IPR029044 Nucleotide-diphospho-sugar transferases

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 1

Summaries

All 60

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:341996 Bowen EE, et al., Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation. Med. 2023 Oct 16;

TSS for A4galt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135651	Chr15:83135921-83135937 (-)	1 bp
Tssr135650	Chr15:83122163-83122185 (-)	13,756 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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