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Fbxw15 Gene Detail
Summary
  • Symbol
    Fbxw15
  • Name
    F-box and WD-40 domain protein 15
  • Synonyms
    Fbxo12J
Location &
Maps
more
  • Sequence Map
    Chr9:109381670-109397330 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3505701
 protein coding gene Chr9:109381670-109397330 (-)
129S1/SvImJ ENSMUSG00200040349
 protein coding gene Chr9:106474696-106490464 (-)
A/J ENSMUSG00195043632
 protein coding gene Chr9:105760089-105775740 (-)
AKR/J ENSMUSG00220026187
 protein coding gene Chr9:106095837-106111489 (-)
BALB/cJ ENSMUSG00180033714
 protein coding gene Chr9:106215030-106230678 (-)
C3H/HeJ ENSMUSG00175032727
 protein coding gene Chr9:106430928-106446572 (-)
C57BL/6NJ ENSMUSG00215026632
 protein coding gene Chr9:106318346-106334008 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005025089
 protein coding gene Chr9:106139057-106154857 (-)
CBA/J ENSMUSG00210030564
 protein coding gene Chr9:106156288-106171937 (-)
DBA/2J ENSMUSG00185040835
 protein coding gene Chr9:106478914-106494558 (-)
FVB/NJ ENSMUSG00205047085
 protein coding gene Chr9:106417933-106433709 (-)
JF1/MsJ ENSUMUG00000027194
 protein coding gene Chr9:106258379-106274042 (-)
LP/J ENSMUSG00230047009
 protein coding gene Chr9:106606905-106622673 (-)
NOD/ShiLtJ ENSMUSG00190036094
 protein coding gene Chr9:106066585-106082229 (-)
NZO/HlLtJ ENSMUSG00225023704
 protein coding gene Chr9:106845002-106860724 (-)
PWK/PhJ ENSLUMG00010035384
 protein coding gene Chr9:106273816-106289494 (-)
SPRET/EiJ ENSMSPG00010032636
 protein coding gene Chr9:108032257-108047840 (-)
WSB/EiJ ENSIUOG00005045335
 protein coding gene Chr9:105520704-105536405 (-)



Homology
more
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Synonyms
    FBW12, FBXO12, FBXO35
  • Links
    NCBI Gene ID: 285231
    UniProt: Q6X9E4

  • Chr Location
    3p21.31; chr3:48372219-48401259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382105 NCBI Gene Model | MGI Sequence Detail 15661 C57BL/6J ±  kb
    transcript NM_199036 RefSeq | MGI Sequence Detail 1520 C57BL/6  
    polypeptide L7N1X6 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR052121 F-box Protein Family Substrate Recognition Components
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 1
    References
    more
    • Summaries
      All 24
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:93441 Jin J, et al., Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Dec 1;18(21):2573-80
    • Latest
      J:348425 Pham AH, et al., Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024;13(10):802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory