Fbxw13 Gene Detail

Summary

• Symbol
  Fbxw13
• Name
  F-box and WD-40 domain protein 13

• Feature Type
  protein coding gene
• IDs
  MGI:3505590
  NCBI Gene: 211305
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr9:109008295-109025043 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 59.63 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  28 from dbSNP Build 142
• Strain Annotations
  15

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3505590	protein coding gene	Chr9:109008295-109025043 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035329	protein coding gene	Chr9:111162533-111182123 (-)
A/J	MGP_AJ_G0035308	protein coding gene	Chr9:107073325-107090068 (-)
AKR/J	MGP_AKRJ_G0035240	protein coding gene	Chr9:109767292-109783886 (-)
BALB/cJ	MGP_BALBcJ_G0035303	protein coding gene	Chr9:106762700-106781145 (-)
C3H/HeJ	MGP_C3HHeJ_G0035012	protein coding gene	Chr9:110148098-110165288 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035822	protein coding gene	Chr9:114173709-114191472 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0034323	protein coding gene	Chr9:110119970-110453478 (-)
CBA/J	MGP_CBAJ_G0034980	protein coding gene	Chr9:118216621-118233364 (-)
DBA/2J	MGP_DBA2J_G0035141	protein coding gene	Chr9:106534638-106551793 (-)
FVB/NJ	MGP_FVBNJ_G0035089	protein coding gene	Chr9:105345286-105362786 (-)
LP/J	MGP_LPJ_G0035217	protein coding gene	Chr9:111348293-111365030 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035128	protein coding gene	Chr9:119765657-119783817 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035843	protein coding gene	Chr9:110059527-110077096 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0034444	protein coding gene	Chr9:109922540-109941279 (-)

Homology

• Human Ortholog
  FBXW12, F-box and WD repeat domain containing 12

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FBXW12, F-box and WD repeat domain containing 12
  
• Synonyms
  FBW12, FBXO12, FBXO35
• Links
  HGNC:20729

  NCBI Gene ID: 285231

  neXtProt AC: NX_Q6X9E4

  UniProt: Q6X9E4

  
  
• Chr Location
  3p21.31; chr3:48372219-48401259 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fbxw13 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: FBXW12
• Gene Tree
  Fbxw13
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  24 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS23548.1

• Ensembl
  ENSMUSG00000049314 (Evidence)
• NCBI Gene
  211305

Representative Sequences			Length	Strain/Species
genomic	211305	NCBI Gene Model | MGI Sequence Detail	16749	C57BL/6J
transcript	NM_177598	RefSeq | MGI Sequence Detail	1485	C57BL/6
polypeptide	NP_808266	RefSeq | MGI Sequence Detail	466	C57BL/6

Protein
Information

• UniProt
  4 Sequences
• InterPro Domains
  IPR001810 F-box domain
  IPR036047 F-box-like domain superfamily
  IPR036322 WD40-repeat-containing domain superfamily
  IPR015943 WD40/YVTN repeat-like-containing domain superfamily

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 2

References

• Summaries
  All 17

  Gene Ontology 1

  Phenotypes 3
• Earliest
  J:93441 Jin J, et al., Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Dec 1;18(21):2573-80
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42