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Rnase9 Gene Detail
Summary
  • Symbol
    Rnase9
  • Name
    ribonuclease, RNase A family, 9 (non-active)
  • Feature Type
    protein coding gene
  • IDs
    MGI:3057273
    NCBI Gene: 328401
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51275916-51279326 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.35 cM, cytoband B-C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3057273
 protein coding gene Chr14:51275916-51279360 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021267
 protein coding gene Chr14:44985773-44989185 (-)
A/J MGP_AJ_G0021221
 protein coding gene Chr14:43639161-43642573 (-)
AKR/J MGP_AKRJ_G0021197
 protein coding gene Chr14:45288493-45291905 (-)
BALB/cJ MGP_BALBcJ_G0021224
 protein coding gene Chr14:43762564-43765976 (-)
C3H/HeJ MGP_C3HHeJ_G0021006
 protein coding gene Chr14:45110934-45114346 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021661
 protein coding gene Chr14:46848896-46852306 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019213
 protein coding gene Chr14:42974771-42978151 (-)
CAST/EiJ MGP_CASTEiJ_G0020530
 protein coding gene Chr14:42185859-42189259 (-)
CBA/J MGP_CBAJ_G0020973
 protein coding gene Chr14:48302988-48306400 (-)
DBA/2J MGP_DBA2J_G0021097
 protein coding gene Chr14:43533543-43536953 (-)
FVB/NJ MGP_FVBNJ_G0021078
 protein coding gene Chr14:43158500-43161912 (-)
LP/J MGP_LPJ_G0021165
 protein coding gene Chr14:45277332-45280744 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021106
 protein coding gene Chr14:47793859-47797271 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021690
 protein coding gene Chr14:44770628-44774040 (-)
PWK/PhJ MGP_PWKPhJ_G0020280
 protein coding gene Chr14:40437331-40440743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020105
 protein coding gene Chr14:40945288-40948655 (-)
WSB/EiJ MGP_WSBEiJ_G0020583
 protein coding gene Chr14:44974053-44977463 (-)



Homology
more
  • Human Ortholog
    RNASE9, ribonuclease A family member 9 (inactive)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE9, ribonuclease A family member 9 (inactive)
  • Synonyms
    h461, HEL128, RAK1
  • Links
    NCBI Gene ID: 390443
    UniProt: P60153

  • Chr Location
    14q11.2; chr14:20556093-20561047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Targeted
    6
  • Genomic Mutations
    2 involving Rnase9
  • Find Mice (IMSR)
    17 strains or lines available
Mice homozygous for a null allele are viable, fertile and overtly normal. However, male homozygotes display impaired sperm maturation during epididymal transit.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052382 Ensembl Gene Model | MGI Sequence Detail 3411 C57BL/6J ±  kb
transcript ENSMUST00000064214 Ensembl | MGI Sequence Detail 1189 Not Applicable  
polypeptide ENSMUSP00000066637 Ensembl | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:93827 Penttinen J, et al., Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. Mol Endocrinol. 2003 Nov;17(11):2138-51
  • Latest
    J:364178 Shaffer JF, et al., Epididymis-specific RNase A family genes regulate fertility and small RNA processing. J Biol Chem. 2024 Oct 28;300(12):107933
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory