Pappa2 MGI Mouse Gene Detail - MGI:3051647

Symbol

Pappa2
Name

pappalysin 2
Synonyms

PAPP-A2, Pappe, PLAC3, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E

Feature Type

protein coding gene
IDs

MGI:3051647
NCBI Gene: 23850
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:158539297-158788019 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 68.49 cM
Mapping Data

2 experiments

SNPs within 2kb

2065 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3051647	protein coding gene	Chr1:158539297-158808060 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016636	protein coding gene	Chr1:163816607-164104591 (-)
A/J	MGP_AJ_G0016617	protein coding gene	Chr1:157177472-157442487 (-)
AKR/J	MGP_AKRJ_G0016583	protein coding gene	Chr1:161983954-162264096 (-)
BALB/cJ	MGP_BALBcJ_G0016578	protein coding gene	Chr1:157701872-157963469 (-)
C3H/HeJ	MGP_C3HHeJ_G0016402	protein coding gene	Chr1:162134657-162416173 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017039	protein coding gene	Chr1:169418090-169713019 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014748	protein coding gene	Chr1:149343148-149605194 (-)
CAST/EiJ	MGP_CASTEiJ_G0015982	protein coding gene	Chr1:161714794-162006884 (-)
CBA/J	MGP_CBAJ_G0016377	protein coding gene	Chr1:175392712-175695536 (-)
DBA/2J	MGP_DBA2J_G0016483	protein coding gene	Chr1:156130272-156393525 (-)
FVB/NJ	MGP_FVBNJ_G0016481	protein coding gene	Chr1:154578471-154857210 (-)
LP/J	MGP_LPJ_G0016554	protein coding gene	Chr1:164916307-165205070 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016506	protein coding gene	Chr1:182942269-183238776 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017075	protein coding gene	Chr1:161829037-162118400 (-)
PWK/PhJ	MGP_PWKPhJ_G0015768	protein coding gene	Chr1:155259386-155530362 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0016044	protein coding gene	Chr1:161944909-162232524 (-)

Human Ortholog

PAPPA2, pappalysin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAPPA2, pappalysin 2
Synonyms

PAPP-A2, PAPPE, PAPP-E, PLAC3, SSDA
Links

HGNC:14615

NCBI Gene ID: 60676

neXtProt AC: NX_Q9BXP8

UniProt: Q9BXP8
Chr Location

1q25.2; chr1:176463171-176845601 (+) GRCh38

MGI Vertebrate Homology

Pappa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAPPA2
Gene Tree

Pappa2

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Phenotype Summary

21 phenotypes from 7 alleles in 7 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

5
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

2 involving Pappa2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

87 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

932
Tissues

136
cDNA Data

35
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pappa2

ZFIN pappa2

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All Sequences

42
RefSeq

6
UniProt

4
CCDS

CCDS48409.1

Ensembl

ENSMUSG00000073530 (Evidence)
NCBI Gene

23850

			Length	Strain/Species	Flank
genomic	23850	NCBI Gene Model \| MGI Sequence Detail	248723	C57BL/6J	± kb
transcript	NM_001085376	RefSeq \| MGI Sequence Detail	8975	C57BL/6
polypeptide	NP_001078845	RefSeq \| MGI Sequence Detail	1789	C57BL/6

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UniProt

4 Sequences
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR036116 Fibronectin type III superfamily

IPR006558 LamG-like jellyroll fold

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR011936 Myxococcus cysteine-rich repeat

IPR000800 Notch domain

IPR043543 Pappalysin-1/2

IPR008754 Peptidase M43, pregnancy-associated plasma-A

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 41

cDNA 37

Primer pair 3

Other 1

Microarray probesets 4

Summaries

All 50

Developmental Gene Expression 11

Gene Ontology 5

Phenotypes 16
Earliest

J:6660 Rougeon F, et al., Molecular cloning of a mouse submaxillary gland renin cDNA fragment. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6367-71
Latest

J:327983 Wang J, et al., Placenta-specific lncRNA 1600012P17Rik is expressed in spongiotrophoblast and glycogen trophoblast cells of mouse placenta. Histochem Cell Biol. 2022 Jul;158(1):65-78

TSS for Pappa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14502	Chr1:158785739-158785750 (-)	2,274 bp
Tssr14501	Chr1:158781060-158781063 (-)	6,957 bp
Tssr14500	Chr1:158715352-158715354 (-)	72,666 bp
Tssr14499	Chr1:158656501-158656507 (-)	131,515 bp
Tssr14498	Chr1:158650386-158650390 (-)	137,631 bp
Tssr14497	Chr1:158540500-158540511 (-)	247,513 bp
Tssr14496	Chr1:158540460-158540465 (-)	247,556 bp
Tssr14495	Chr1:158540433-158540441 (-)	247,582 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23