Cpa6 MGI Mouse Gene Detail - MGI:3045348

Symbol

Cpa6
Name

carboxypeptidase A6
Synonyms

9030616D13Rik

Feature Type

protein coding gene
IDs

MGI:3045348
NCBI Gene: 329093
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:10394945-10790170 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 2.45 cM
Mapping Data

1 experiment

SNPs within 2kb

10996 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045348	protein coding gene	Chr1:10366016-10790277 (-)
129S1/SvImJ	ENSMUSG00200002413	protein coding gene	Chr1:7730515-8141947 (-)
A/J	ENSMUSG00195002862	protein coding gene	Chr1:7537157-7973725 (-)
AKR/J	ENSMUSG00220003346	protein coding gene	Chr1:7637555-8043878 (-)
BALB/cJ	ENSMUSG00180008684	protein coding gene	Chr1:7620687-8039845 (-)
C3H/HeJ	ENSMUSG00175000288	protein coding gene	Chr1:7533227-7932651 (-)
C57BL/6NJ	ENSMUSG00215004037	protein coding gene	Chr1:7579506-7976343 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013948	protein coding gene	Chr1:6500287-6864636 (-)
CAST/EiJ	ENSTCUG00005001796	protein coding gene	Chr1:7971837-8375449 (-)
CBA/J	ENSMUSG00210001558	protein coding gene	Chr1:7392683-7792001 (-)
DBA/2J	ENSMUSG00185004410	protein coding gene	Chr1:8465070-8862148 (-)
FVB/NJ	ENSMUSG00205004833	protein coding gene	Chr1:7714532-8126831 (-)
JF1/MsJ	ENSUMUG00000002404	protein coding gene	Chr1:7747256-8150724 (-)
LP/J	ENSMUSG00230002215	protein coding gene	Chr1:8472199-8883264 (-)
NOD/ShiLtJ	ENSMUSG00190001166	protein coding gene	Chr1:7528972-7940171 (-)
NZO/HlLtJ	ENSMUSG00225005088	protein coding gene	Chr1:11863071-12274125 (-)
PWK/PhJ	ENSLUMG00010002219	protein coding gene	Chr1:7353495-7752952 (-)
SPRET/EiJ	ENSMSPG00010013548	protein coding gene	Chr1:7975472-8410043 (-)
WSB/EiJ	ENSIUOG00005010610	protein coding gene	Chr1:7543829-7941041 (-)

Human Ortholog

CPA6, carboxypeptidase A6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPA6, carboxypeptidase A6
Synonyms

CPAH, ETL5, FEB11
Links

HGNC:17245

NCBI Gene ID: 57094

UniProt: Q8N4T0
Chr Location

8q13.2; chr8:67422038-67746378 (-) GRCh38

MGI Vertebrate Homology

Cpa6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CPA6
Gene Tree

Cpa6

Diseases

2 with human CPA6 associations

				Human Disease	Mouse Models
				familial febrile seizures 11 IDs familial febrile seizures 11 DOID:0111308 OMIM:614418
				familial temporal lobe epilepsy 5 IDs familial temporal lobe epilepsy 5 DOID:0060752 OMIM:614417 ORDO:163717

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

661
Tissues

35
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpa6

ZFIN cpa6

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All Sequences

47
RefSeq

10
UniProt

3
CCDS

CCDS14819.1

Ensembl

ENSMUSG00000042501 (Evidence)
NCBI Gene

329093

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042501	Ensembl Gene Model \| MGI Sequence Detail	395226	C57BL/6J	± kb
transcript	ENSMUST00000035577	Ensembl \| MGI Sequence Detail	1932	Not Applicable
polypeptide	ENSMUSP00000035435	Ensembl \| MGI Sequence Detail	438	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005800 carboxypeptidase A6

(term hierarchy)
EC

3.4.17.-
InterPro Domains

IPR003146 Carboxypeptidase, activation peptide

IPR036990 Metallocarboxypeptidase-like, propeptide

IPR000834 Peptidase M14, carboxypeptidase A

IPR057247 Zinc carboxypeptidases, zinc-binding region 2
GlyGen

Q5U901 4 sites

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 26

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 6
Earliest

J:99338 Fontenele-Neto JD, et al., Identification and distribution of mouse carboxypeptidase A-6. Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):132-42
Latest

J:361746 Hata K, et al., Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. J Cell Physiol. 2025 Jan;240(1):e31490

TSS for Cpa6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10969	Chr1:10790123-10790164 (-)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24