Cdcp2 MGI Mouse Gene Detail - MGI:3045328 - CUB domain containing protein 2

Symbol

Cdcp2
Name

CUB domain containing protein 2
Synonyms

D030010E02Rik

Feature Type

protein coding gene
IDs

MGI:3045328
NCBI Gene: 242603
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:106954088-106970322 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.02 cM
Mapping Data

1 experiment

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045328	protein coding gene	Chr4:106954088-106971420 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028531	protein coding gene	Chr4:107766638-107777660 (+)
A/J	MGP_AJ_G0028494	protein coding gene	Chr4:103905041-103915905 (+)
AKR/J	MGP_AKRJ_G0028441	protein coding gene	Chr4:106441418-106455861 (+)
BALB/cJ	MGP_BALBcJ_G0028513	protein coding gene	Chr4:104095451-104106767 (+)
C3H/HeJ	MGP_C3HHeJ_G0028227	protein coding gene	Chr4:107196239-107207122 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028953	protein coding gene	Chr4:111647517-111658381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026244	protein coding gene	Chr4:99184955-99196336 (+)
CAST/EiJ	MGP_CASTEiJ_G0027663	protein coding gene	Chr4:105010641-105021325 (+)
CBA/J	MGP_CBAJ_G0028196	protein coding gene	Chr4:115261236-115272100 (+)
DBA/2J	MGP_DBA2J_G0028344	protein coding gene	Chr4:103522175-103533027 (+)
FVB/NJ	MGP_FVBNJ_G0028312	protein coding gene	Chr4:102390870-102401801 (+)
LP/J	MGP_LPJ_G0028445	protein coding gene	Chr4:107963916-107974793 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028338	protein coding gene	Chr4:120562762-120573626 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028989	protein coding gene	Chr4:106683482-106694371 (+)
PWK/PhJ	MGP_PWKPhJ_G0027389	protein coding gene	Chr4:101769551-101780360 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027213	protein coding gene	Chr4:104087116-104097941 (+)
WSB/EiJ	MGP_WSBEiJ_G0027744	protein coding gene	Chr4:106867814-106879847 (+)

Human Ortholog

CDCP2, CUB domain containing protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDCP2, CUB domain containing protein 2
Links

HGNC:27297

NCBI Gene ID: 200008

neXtProt AC: NX_Q5VXM1

UniProt: Q5VXM1
Chr Location

1p32.3; chr1:54138995-54153006 (-) GRCh38.p7

Alliance of Genome Resources

Cdcp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDCP2
Gene Tree

Cdcp2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Cdcp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdcp2

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Cdcp2 interacts with 72 markers (Mir17, Mir20b, Mir106a, ...) View All

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All Sequences

31
RefSeq

4
UniProt

2
CCDS

CCDS18430.1

Ensembl

ENSMUSG00000047636 (Evidence)
NCBI Gene

242603

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047636	Ensembl Gene Model \| MGI Sequence Detail	16235	C57BL/6J	± kb
transcript	ENSMUST00000221740	Ensembl \| MGI Sequence Detail	1623	Not Applicable
polypeptide	ENSMUSP00000152236	Ensembl \| MGI Sequence Detail	540	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031174 CUB domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000859 CUB domain

IPR035914 Spermadhesin, CUB domain superfamily

IPR001507 Zona pellucida domain

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All nucleic 2

cDNA 2

Microarray probesets 1

Summaries

All 26

Gene Ontology 1

Phenotypes 12
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:148802 Boles MK, et al., A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009;10:12

TSS for Cdcp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38215	Chr4:106954794-106954800 (+)	709 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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