Trdnos Gene Detail

Summary

• Symbol
  Trdnos
• Name
  triadin, opposite strand
• Synonyms
  D830005E20Rik, Trdn-as

• Feature Type
  lncRNA gene
• IDs
  MGI:3045284
  NCBI Gene: 442820
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr10:33098341-33132353 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  981 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045284	lncRNA gene	Chr10:33075157-33132423 (-)
129S1/SvImJ	ENSMUSG00200010772	lncRNA gene	Chr10:29940922-29974999 (-)
A/J	ENSMUSG00195014410	lncRNA gene	Chr10:30219164-30253237 (-)
AKR/J	ENSMUSG00220011392	lncRNA gene	Chr10:29907309-29941382 (-)
BALB/cJ	ENSMUSG00180018781	lncRNA gene	Chr10:30339199-30373272 (-)
C3H/HeJ	ENSMUSG00175026771	lncRNA gene	Chr10:30094120-30128194 (-)
C57BL/6NJ	ENSMUSG00215013499	lncRNA gene	Chr10:29882355-29916429 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005013933	lncRNA gene	Chr10:29705423-29737267 (-)
CBA/J	ENSMUSG00210023692	lncRNA gene	Chr10:30021603-30055677 (-)
DBA/2J	ENSMUSG00185007363	lncRNA gene	Chr10:30174434-30208506 (-)
FVB/NJ	ENSMUSG00205010626	lncRNA gene	Chr10:30169508-30203582 (-)
JF1/MsJ	ENSUMUG00000019858	lncRNA gene	Chr10:29933324-29965048 (-)
LP/J	ENSMUSG00230015818	lncRNA gene	Chr10:31939955-31974028 (-)
NOD/ShiLtJ	ENSMUSG00190015751	lncRNA gene	Chr10:30287428-30321501 (-)
NZO/HlLtJ	ENSMUSG00225034241	lncRNA gene	Chr10:36198362-36232435 (-)
PWK/PhJ	ENSLUMG00010010500	lncRNA gene	Chr10:29900045-29931617 (-)
SPRET/EiJ	ENSMSPG00010021589	lncRNA gene	Chr10:30921990-30957268 (-)
WSB/EiJ	ENSIUOG00005032605	lncRNA gene	Chr10:29729932-29765034 (-)

Homology

• Gene Tree
  Trdnos
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving Trdnos
• Find Mice (IMSR)
  0 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele show downregulation of cardiac triadin, impaired Ca2+ handling and cardiac function, reduced exercise capacity, predisposition to cardiac arrhythmias in response to catecholamine challenge, and premature death.

Expression

• Assay Results
  597
• cDNA Data
  2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  1

• Ensembl
  ENSMUSG00000112707 (Evidence)
• NCBI Gene
  442820

Representative Sequences			Length	Strain/Species
genomic	442820	NCBI Gene Model | MGI Sequence Detail	34013	C57BL/6J
transcript	NR_040657	RefSeq | MGI Sequence Detail	1844	C57BL/6

Molecular
Reagents

• All nucleic 2

  cDNA 2

Other
Accession IDs

MGI:8240193

References

• Summaries
  All 14

  Phenotypes 7
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:364653 Zhao Y, et al., Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714

TSS for Trdnos:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97227	Chr10:33132365-33132378 (-)	-19 bp
Tssr97226	Chr10:33132340-33132358 (-)	4 bp
Tssr97225	Chr10:33132227-33132240 (-)	119 bp