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Fat4 Gene Detail
Summary
  • Symbol
    Fat4
  • Name
    FAT atypical cadherin 4
  • Synonyms
    6030410K14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045256
    NCBI Gene: 329628
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:38941089-39066134 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 18.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3905 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045256
 protein coding gene Chr3:38939867-39066134 (+)
129S1/SvImJ ENSMUSG00200005502
 protein coding gene Chr3:35670157-35794932 (+)
A/J ENSMUSG00195001369
 protein coding gene Chr3:35641680-35766596 (+)
AKR/J ENSMUSG00220000578
 protein coding gene Chr3:35746202-35871072 (+)
BALB/cJ ENSMUSG00180002279
 protein coding gene Chr3:35797059-35922086 (+)
C3H/HeJ ENSMUSG00175003278
 protein coding gene Chr3:35685608-35810500 (+)
C57BL/6NJ ENSMUSG00215001299
 protein coding gene Chr3:36077283-36202361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024955
 protein coding gene Chr3:33672026-33798717 (+)
CAST/EiJ ENSTCUG00005000840
 protein coding gene Chr3:35516535-35644108 (+)
CBA/J ENSMUSG00210001366
 protein coding gene Chr3:35739957-35864852 (+)
DBA/2J ENSMUSG00185000952
 protein coding gene Chr3:35956323-36081174 (+)
FVB/NJ ENSMUSG00205000374
 protein coding gene Chr3:35109409-35235671 (+)
JF1/MsJ ENSUMUG00000000402
 protein coding gene Chr3:35491134-35617436 (+)
LP/J ENSMUSG00230023298
 protein coding gene Chr3:37915173-38039936 (+)
NOD/ShiLtJ ENSMUSG00190001029
 protein coding gene Chr3:36015283-36140144 (+)
NZO/HlLtJ ENSMUSG00225000335
 protein coding gene Chr3:40536092-40660859 (+)
PWK/PhJ ENSLUMG00010000608
 protein coding gene Chr3:35520044-35646093 (+)
SPRET/EiJ ENSMSPG00010000441
 protein coding gene Chr3:35945165-36072275 (+)
WSB/EiJ ENSIUOG00005013469
 protein coding gene Chr3:35962396-36087297 (+)



Homology
more
  • Human Ortholog
    FAT4, FAT atypical cadherin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAT4, FAT atypical cadherin 4
  • Synonyms
    CDHF14, CDHR11, FAT-J, FATJ, HKLLS2, NBLA00548, VMLDS2
  • Links
    NCBI Gene ID: 79633
    UniProt: Q6V0I7

  • Chr Location
    4q28.1; chr4:125314918-125492932 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FAT4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to neonatal lethality, reduced birth body size, curly tails, kyphosis, small lungs, renal cysts, and defects in sternum and vertebrae morphology, neural tube width, cochlear elongation, stereocilia orientation, kidney development, and intestinal elongation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    43
  • cDNA Data
    44
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046743 Ensembl Gene Model | MGI Sequence Detail 125046 C57BL/6J ±  kb
    transcript ENSMUST00000061260 Ensembl | MGI Sequence Detail 16109 Not Applicable  
    polypeptide ENSMUSP00000061836 Ensembl | MGI Sequence Detail 4981 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 45
      Primer pair 3
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:377804 Halasz G, et al., Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis. Nat Commun. 2025 Nov 19;16(1):10173
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory