About   Help   FAQ
Wdr25 Gene Detail
Summary
  • Symbol
    Wdr25
  • Name
    WD repeat domain 25
  • Synonyms
    B930090D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045255
    NCBI Gene: 212198
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108860155-108994380 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2946 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045255
 protein coding gene Chr12:108859557-108994380 (+)
129S1/SvImJ ENSMUSG00200023216
 protein coding gene Chr12:100637141-100637596 (+)
A/J ENSMUSG00195043896
 protein coding gene Chr12:103198106-103198561 (+)
AKR/J ENSMUSG00220039260
 protein coding gene Chr12:101080021-101080476 (+)
BALB/cJ ENSMUSG00180045218
 protein coding gene Chr12:102400237-102400692 (+)
C3H/HeJ ENSMUSG00175032788
 protein coding gene Chr12:105007993-105008448 (+)
C57BL/6NJ ENSMUSG00215045920
 protein coding gene Chr12:101673175-101673630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018109
 protein coding gene Chr12:103355564-103490511 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210027769
 protein coding gene Chr12:102069574-102070029 (+)
DBA/2J ENSMUSG00185026099
 protein coding gene Chr12:103857502-103857957 (+)
FVB/NJ ENSMUSG00205016853
 protein coding gene Chr12:101087739-101088194 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230030142
 protein coding gene Chr12:110902072-110902527 (+)
NOD/ShiLtJ ENSMUSG00190020575
 protein coding gene Chr12:84145132-84145587 (-)
NZO/HlLtJ ENSMUSG00225036823
 protein coding gene Chr12:112660785-112661240 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010015819
 protein coding gene Chr12:104389197-104521787 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Synonyms
    C14orf67
  • Links
    NCBI Gene ID: 79446
    UniProt: Q64LD2

  • Chr Location
    14q32.2; chr14:100376418-100530306 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212198 NCBI Gene Model | MGI Sequence Detail 134226 C57BL/6J ±  kb
    transcript NM_177602 RefSeq | MGI Sequence Detail 2657 C57BL/6  
    polypeptide E9Q349 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Phenotypes 12
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory