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Wdr25 Gene Detail
Summary
  • Symbol
    Wdr25
  • Name
    WD repeat domain 25
  • Synonyms
    B930090D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045255
    NCBI Gene: 212198
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108860155-108994380 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045255
protein coding gene Chr12:108859557-108994380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020112
protein coding gene Chr12:111055911-111204481 (+)
A/J MGP_AJ_G0020066
protein coding gene Chr12:106833777-106970841 (+)
AKR/J MGP_AKRJ_G0020042
protein coding gene Chr12:109931117-110089437 (+)
BALB/cJ MGP_BALBcJ_G0020052
protein coding gene Chr12:107254734-107387435 (+)
C3H/HeJ MGP_C3HHeJ_G0019854
protein coding gene Chr12:110379078-110527780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020497
protein coding gene Chr12:114470437-114616258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018109
protein coding gene Chr12:103355564-103490511 (+)
CAST/EiJ MGP_CASTEiJ_G0019396
protein coding gene Chr12:105323356-105468409 (+)
CBA/J MGP_CBAJ_G0019821
protein coding gene Chr12:119034798-119200499 (+)
DBA/2J MGP_DBA2J_G0019938
protein coding gene Chr12:106370487-106505051 (+)
FVB/NJ MGP_FVBNJ_G0019923
protein coding gene Chr12:105161367-105299676 (+)
LP/J MGP_LPJ_G0020013
protein coding gene Chr12:110919190-111063754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019961
protein coding gene Chr12:122174557-122320381 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020526
protein coding gene Chr12:109415458-109553076 (+)
PWK/PhJ MGP_PWKPhJ_G0019155
protein coding gene Chr12:100992524-101130177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018959
protein coding gene Chr12:103620535-103762642 (+)
WSB/EiJ MGP_WSBEiJ_G0019453
protein coding gene Chr12:110353586-110496273 (+)



Homology
more
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Synonyms
    C14orf67
  • Links
    NCBI Gene ID: 79446
    neXtProt AC: NX_Q64LD2
    UniProt: Q64LD2

  • Chr Location
    14q32.2; chr14:100376418-100530303 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 212198 NCBI Gene Model | MGI Sequence Detail 134226 C57BL/6J ±  kb
transcript NM_177602 RefSeq | MGI Sequence Detail 2657 C57BL/6  
polypeptide E9Q349 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory