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Prmt8 Gene Detail
Summary
  • Symbol
    Prmt8
  • Name
    protein arginine N-methyltransferase 8
  • Synonyms
    Hrmt1l3, Hrmt1l4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043083
    NCBI Gene: 381813
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127665972-127746430 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 62.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3043083
 protein coding gene Chr6:127665972-127746435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031316
 protein coding gene Chr6:131223913-131305991 (-)
A/J MGP_AJ_G0031287
 protein coding gene Chr6:126211975-126293340 (-)
AKR/J MGP_AKRJ_G0031215
 protein coding gene Chr6:129616004-129698176 (-)
BALB/cJ MGP_BALBcJ_G0031294
 protein coding gene Chr6:125774624-125856342 (-)
C3H/HeJ MGP_C3HHeJ_G0031018
 protein coding gene Chr6:129760280-129844417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031751
 protein coding gene Chr6:134650797-134735350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028899
 protein coding gene Chr6:123384847-123466550 (-)
CAST/EiJ MGP_CASTEiJ_G0030399
 protein coding gene Chr6:129984608-130071927 (-)
CBA/J MGP_CBAJ_G0030979
 protein coding gene Chr6:139817705-139907401 (-)
DBA/2J MGP_DBA2J_G0031135
 protein coding gene Chr6:125102335-125183268 (-)
FVB/NJ MGP_FVBNJ_G0031084
 protein coding gene Chr6:124025328-124108579 (-)
LP/J MGP_LPJ_G0031215
 protein coding gene Chr6:131319426-131400652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031123
 protein coding gene Chr6:143731382-143816056 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031786
 protein coding gene Chr6:129596634-129681426 (-)
PWK/PhJ MGP_PWKPhJ_G0030114
 protein coding gene Chr6:123363457-123464969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029943
 protein coding gene Chr6:127696263-127781824 (-)
WSB/EiJ MGP_WSBEiJ_G0030484
 protein coding gene Chr6:129966291-130050098 (-)



Homology
more
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
  • Synonyms
    HRMT1L3, HRMT1L4
  • Links
    NCBI Gene ID: 56341
    neXtProt AC: NX_Q9NR22
    UniProt: Q9NR22

  • Chr Location
    12p13.32; chr12:3381349-3593973 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit abnormal Purkinje cell dendrite morphology, hyperactivity, limb grasping and gait abnormalities, and show reduced levels of acetylcholine and choline along with increased phosphatidylcholine levels in the cerebellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    113
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381813 NCBI Gene Model | MGI Sequence Detail 80459 C57BL/6J ±  kb
    transcript NR_157230 RefSeq | MGI Sequence Detail 2452 C57BL/6  
    polypeptide Q6PAK3 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 15
      Primer pair 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:85485 Alappat SR, et al., Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis. Dev Dyn. 2003 Sep;228(1):59-71
    • Latest
      J:321778 Couto E Silva A, et al., Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress. J Neurochem. 2021 Nov;159(4):742-761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory