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Tcaf3 Gene Detail
Summary
  • Symbol
    Tcaf3
  • Name
    TRPM8 channel-associated factor 3
  • Synonyms
    Eapa2, Fam115e
  • Feature Type
    protein coding gene
  • IDs
    MGI:3042585
    NCBI Gene: 403088
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:42564147-42574306 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 20.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3042585
 protein coding gene Chr6:42561800-42574626 (-)
129S1/SvImJ ENSMUSG00200042996
 protein coding gene Chr6:39623244-39633724 (-)
A/J ENSMUSG00195033842
 protein coding gene Chr6:39592029-39602513 (-)
AKR/J ENSMUSG00220008066
 protein coding gene Chr6:39194053-39204530 (-)
BALB/cJ ENSMUSG00180042323
 protein coding gene Chr6:39720429-39730912 (-)
C3H/HeJ ENSMUSG00175047208
 protein coding gene Chr6:39547507-39557982 (-)
C57BL/6NJ ENSMUSG00215047419
 protein coding gene Chr6:39675444-39685923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028301
 protein coding gene Chr6:37190724-37202944 (-)
CAST/EiJ ENSTCUG00005034145
 protein coding gene Chr6:39134300-39144799 (-)
CBA/J ENSMUSG00210048474
 protein coding gene Chr6:39599196-39609671 (-)
DBA/2J ENSMUSG00185039314
 protein coding gene Chr6:39701681-39712158 (-)
FVB/NJ ENSMUSG00205048146
 protein coding gene Chr6:39611072-39621544 (-)
JF1/MsJ ENSUMUG00000013393
 protein coding gene Chr6:39231821-39242296 (-)
LP/J ENSMUSG00230041872
 protein coding gene Chr6:40625330-40635807 (-)
NOD/ShiLtJ ENSMUSG00190028451
 protein coding gene Chr6:39507606-39518087 (-)
NZO/HlLtJ ENSMUSG00225018004
 protein coding gene Chr6:42607994-42618477 (-)
PWK/PhJ ENSLUMG00010039497
 protein coding gene Chr6:39060977-39071511 (-)
SPRET/EiJ ENSMSPG00010026081
 protein coding gene Chr6:39748837-39759327 (-)
WSB/EiJ ENSIUOG00005027021
 protein coding gene Chr6:39834810-39845308 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 403088 NCBI Gene Model | MGI Sequence Detail 10160 C57BL/6J ±  kb
transcript NM_203396 RefSeq | MGI Sequence Detail 3110 C57BL/6  
polypeptide Q6QR59 UniProt | EBI | MGI Sequence Detail 914 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007279 experimental autoimmune prostatitis antigen 2
    (term hierarchy)
  • InterPro Domains
    IPR029062 Class I glutamine amidotransferase-like
    IPR035423 M60-like domain, N-terminal
    IPR031161 Peptidase family M60 domain
    IPR042279 Peptidase M60, enhancin-like domain 3
    IPR060292 TRPM8 channel-associated factor, alpha-helical domain
    IPR060286 TRPM8 channel-associated factor, N-terminal domain
    IPR051244 TRPM8 Channel-Associated Factors
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 17
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:124439 Setiady YY, et al., Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells. Blood. 2006 Feb 1;107(3):1056-62
  • Latest
    J:258941 Leonard JD, et al., Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 Jul 18;47(1):107-117.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory