Dipk1c MGI Mouse Gene Detail - MGI:3041188 - divergent protein kinase domain 1C

Symbol

Dipk1c
Name

divergent protein kinase domain 1C
Synonyms

B230399E16Rik, Fam69c

Feature Type

protein coding gene
IDs

MGI:3041188
NCBI Gene: 240479
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:84737361-84758561 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 57.53 cM
Mapping Data

1 experiment

SNPs within 2kb

826 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3041188	protein coding gene	Chr18:84737133-84762820 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024609	protein coding gene	Chr18:85881995-85902062 (+)
A/J	MGP_AJ_G0024576	protein coding gene	Chr18:82111601-82133604 (+)
AKR/J	MGP_AKRJ_G0024547	protein coding gene	Chr18:84559177-84580584 (+)
BALB/cJ	MGP_BALBcJ_G0024574	protein coding gene	Chr18:82303351-82325133 (+)
C3H/HeJ	MGP_C3HHeJ_G0024343	protein coding gene	Chr18:84660311-84679782 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025021	protein coding gene	Chr18:88019005-88039991 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022452	protein coding gene	Chr18:80803146-80823619 (+)
CAST/EiJ	MGP_CASTEiJ_G0023816	protein coding gene	Chr18:85032645-85059639 (+)
CBA/J	MGP_CBAJ_G0024313	protein coding gene	Chr18:91191498-91217364 (+)
DBA/2J	MGP_DBA2J_G0024442	protein coding gene	Chr18:81631904-81651186 (+)
FVB/NJ	MGP_FVBNJ_G0024409	protein coding gene	Chr18:80968302-80988787 (+)
LP/J	MGP_LPJ_G0024527	protein coding gene	Chr18:85684343-85706469 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024439	protein coding gene	Chr18:92431892-92465175 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025070	protein coding gene	Chr18:84772910-84795115 (+)
PWK/PhJ	MGP_PWKPhJ_G0023561	protein coding gene	Chr18:82028491-82055004 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023367	protein coding gene	Chr18:84800538-84820476 (+)
WSB/EiJ	MGP_WSBEiJ_G0023878	protein coding gene	Chr18:84725993-84748462 (+)

Human Ortholog

DIPK1C, divergent protein kinase domain 1C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DIPK1C, divergent protein kinase domain 1C
Synonyms

C18orf51, FAM69C, FNCAD
Links

HGNC:31729

NCBI Gene ID: 125704

UniProt: Q0P6D2
Chr Location

18q22.3; chr18:74434775-74464648 (-) GRCh38

MGI Vertebrate Homology

Dipk1c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DIPK1C
Gene Tree

Dipk1c

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

1
Transposon induced

1
Genomic Mutations

1 involving Dipk1c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Homozygous null mice exhibit impairments in synaptic plasticity, dendritic spine density, and memory, and show stress-induced neuronal death

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All GO Annotations

12
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

14
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dipk1c

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All Sequences

62
RefSeq

20
UniProt

4
CCDS

CCDS29384.1

Ensembl

ENSMUSG00000047992 (Evidence)
NCBI Gene

240479

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047992	Ensembl Gene Model \| MGI Sequence Detail	21201	C57BL/6J	± kb
transcript	ENSMUST00000161429	Ensembl \| MGI Sequence Detail	1387	Not Applicable
polypeptide	ENSMUSP00000124603	Ensembl \| MGI Sequence Detail	410	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031259 divergent protein kinase domain 1C

(term hierarchy)
InterPro Domains

IPR029244 FAM69, N-terminal

IPR022049 FAM69, protein-kinase domain
GlyGen

Q8BQT2 1 site, 1 N-linked glycan (1 site)

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All nucleic 8

Genomic 2

cDNA 6

Microarray probesets 1

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MGI:6276591

Summaries

All 24

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 8
Earliest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dipk1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152213	Chr18:84737611-84737632 (+)	261 bp
Tssr152214	Chr18:84738268-84738296 (+)	921 bp
Tssr152215	Chr18:84738996-84739014 (+)	1,644 bp
Tssr152216	Chr18:84739266-84739271 (+)	1,908 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/24/2026 MGI 6.24