Zbtb24 MGI Mouse Gene Detail - MGI:3039618 - zinc finger and BTB domain containing 24

Symbol

Zbtb24
Name

zinc finger and BTB domain containing 24
Synonyms

ZNF450

Feature Type

protein coding gene
IDs

MGI:3039618
NCBI Gene: 268294
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:41326379-41341570 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.38 cM
Mapping Data

1 experiment

SNPs within 2kb

447 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039618	protein coding gene	Chr10:41326354-41341578 (+)
129S1/SvImJ	ENSMUSG00200008154	protein coding gene	Chr10:38197430-38212637 (+)
A/J	ENSMUSG00195015364	protein coding gene	Chr10:38487862-38503053 (+)
AKR/J	ENSMUSG00220027495	protein coding gene	Chr10:38164366-38179557 (+)
BALB/cJ	ENSMUSG00180015425	protein coding gene	Chr10:38572985-38588177 (+)
C3H/HeJ	ENSMUSG00175011698	protein coding gene	Chr10:38367254-38382445 (+)
C57BL/6NJ	ENSMUSG00215005897	protein coding gene	Chr10:38116582-38131774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015266	protein coding gene	Chr10:36913535-36928739 (+)
CAST/EiJ	ENSTCUG00005027898	protein coding gene	Chr10:38562949-38578151 (+)
CBA/J	ENSMUSG00210025028	protein coding gene	Chr10:38260720-38275912 (+)
DBA/2J	ENSMUSG00185006686	protein coding gene	Chr10:38413374-38428565 (+)
FVB/NJ	ENSMUSG00205010386	protein coding gene	Chr10:38328527-38343721 (+)
JF1/MsJ	ENSUMUG00000029722	protein coding gene	Chr10:38186759-38201983 (+)
LP/J	ENSMUSG00230005715	protein coding gene	Chr10:40187295-40202501 (+)
NOD/ShiLtJ	ENSMUSG00190024094	protein coding gene	Chr10:38541552-38556743 (+)
NZO/HlLtJ	ENSMUSG00225017632	protein coding gene	Chr10:44506371-44521563 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005014654	protein coding gene	Chr10:38099122-38114330 (+)

Human Ortholog

ZBTB24, zinc finger and BTB domain containing 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB24, zinc finger and BTB domain containing 24
Synonyms

BIF1, ICF2, PATZ2, ZNF450
Links

HGNC:21143

NCBI Gene ID: 9841

UniProt: O43167
Chr Location

6q21; chr6:109460632-109483239 (-) GRCh38

MGI Vertebrate Homology

Zbtb24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB24
Gene Tree

Zbtb24

Diseases

1 with human ZBTB24 associations

				Human Disease	Mouse Models
				immunodeficiency-centromeric instability-facial anomalies syndrome 2 IDs immunodeficiency-centromeric instability-facial anomalies syndrome 2 DOID:0090009 ICD10CM:D84.8 OMIM:614069

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Zbtb24
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a deletion in the BTB domain exhibit embryonic lethality between E4.5 and E9.5. KO in ESCs leads to reduced transcriptional repression of centromeric repeats, hypomethylation of centromeric minor satellite repeats and, in lymphoblastoid cells, to over-expression of innate immune response-related genes.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

662
Tissues

44
cDNA Data

12
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zbtb24

ZFIN zbtb24

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All Sequences

55
RefSeq

10
UniProt

1
CCDS

CCDS23804.1, CCDS87996.1, CCDS87997.1

Ensembl

ENSMUSG00000019826 (Evidence)
NCBI Gene

268294

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019826	Ensembl Gene Model \| MGI Sequence Detail	15192	C57BL/6J	± kb
transcript	ENSMUST00000080771	Ensembl \| MGI Sequence Detail	2844	Not Applicable
polypeptide	ENSMUSP00000079592	Ensembl \| MGI Sequence Detail	710	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017570 zinc finger and BTB domain-containing protein 24

(term hierarchy)
PDB

6ML2, 6ML3, 6ML4, 6ML5, 6ML6, 6ML7
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 6

Summaries

All 43

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:378384 Grillo G, et al., ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats. Hum Mol Genet. 2025 Jan 29;34(2):161-177

TSS for Zbtb24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93044	Chr10:41326359-41326417 (+)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24