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Znrf3 Gene Detail
Summary
  • Symbol
    Znrf3
  • Name
    zinc and ring finger 3
  • Synonyms
    LOC382477
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039616
    NCBI Gene: 407821
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5226329-5394847 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2457 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039616
 protein coding gene Chr11:5226324-5394847 (-)
129S1/SvImJ ENSMUSG00200031831
 protein coding gene Chr11:2181344-2348507 (-)
A/J ENSMUSG00195022336
 protein coding gene Chr11:2088285-2255532 (-)
AKR/J ENSMUSG00220008821
 protein coding gene Chr11:2125752-2292990 (-)
BALB/cJ ENSMUSG00180024580
 protein coding gene Chr11:2111757-2279071 (-)
C3H/HeJ ENSMUSG00175009380
 protein coding gene Chr11:2104464-2273322 (-)
C57BL/6NJ ENSMUSG00215013282
 protein coding gene Chr11:2115011-2283894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016051
 protein coding gene Chr11:2128646-2296181 (-)
CAST/EiJ ENSTCUG00005034927
 protein coding gene Chr11:2198504-2365921 (-)
CBA/J ENSMUSG00210017873
 protein coding gene Chr11:2104077-2272944 (-)
DBA/2J ENSMUSG00185016370
 protein coding gene Chr11:2201847-2370736 (-)
FVB/NJ ENSMUSG00205019879
 protein coding gene Chr11:2090965-2258141 (-)
JF1/MsJ ENSUMUG00000024228
 protein coding gene Chr11:2361622-2527753 (-)
LP/J ENSMUSG00230032525
 protein coding gene Chr11:3264435-3431604 (-)
NOD/ShiLtJ ENSMUSG00190033695
 protein coding gene Chr11:2087854-2255087 (-)
NZO/HlLtJ ENSMUSG00225026002
 protein coding gene Chr11:5322659-5489813 (-)
PWK/PhJ ENSLUMG00010018112
 protein coding gene Chr11:2098301-2265527 (-)
SPRET/EiJ ENSMSPG00010007313
 protein coding gene Chr11:2175340-2338719 (-)
WSB/EiJ ENSIUOG00005007355
 protein coding gene Chr11:2108521-2269453 (-)



Homology
more
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
  • Synonyms
    BK747E2.3, RNF203
  • Links
    NCBI Gene ID: 84133
    UniProt: Q9ULT6

  • Chr Location
    22q12.1; chr22:28883565-29057488 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit complete lethality around birth, aphakia, abnormal lens development and defective enural tube closure in some mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    20
  • cDNA Data
    23
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 407821 NCBI Gene Model | MGI Sequence Detail 168519 C57BL/6J ±  kb
    transcript NM_001290501 RefSeq | MGI Sequence Detail 7199 C57BL/6  
    polypeptide Q5SSZ7 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2686013, MGI:3034979
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:391809 Diegel CR, et al., Deletion of the Wnt regulator Znrf3 alters bone geometry without inducing high bone mass. Bone. 2026 Jul 28;:118032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory