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Dlgap3 Gene Detail
Summary
  • Symbol
    Dlgap3
  • Name
    DLG associated protein 3
  • Synonyms
    DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039563
    NCBI Gene: 242667
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:127062997-127130815 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.33 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    435 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039563
protein coding gene Chr4:127062098-127130815 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028794
protein coding gene Chr4:128906907-128979805 (+)
A/J MGP_AJ_G0028753
protein coding gene Chr4:123823267-123895417 (+)
AKR/J MGP_AKRJ_G0028706
protein coding gene Chr4:127224066-127303023 (+)
BALB/cJ MGP_BALBcJ_G0028776
protein coding gene Chr4:124390987-124459895 (+)
C3H/HeJ MGP_C3HHeJ_G0028490
protein coding gene Chr4:127301206-127372860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029218
protein coding gene Chr4:133812226-133889356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026491
protein coding gene Chr4:116946264-117013924 (+)
CAST/EiJ MGP_CASTEiJ_G0027923
protein coding gene Chr4:125424048-125497644 (+)
CBA/J MGP_CBAJ_G0028456
protein coding gene Chr4:137068091-137160409 (+)
DBA/2J MGP_DBA2J_G0028605
protein coding gene Chr4:124267048-124335937 (+)
FVB/NJ MGP_FVBNJ_G0028572
protein coding gene Chr4:122930200-122997201 (+)
LP/J MGP_LPJ_G0028706
protein coding gene Chr4:129193413-129270389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028598
protein coding gene Chr4:142067198-142139172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029256
protein coding gene Chr4:127602082-127674971 (+)
PWK/PhJ MGP_PWKPhJ_G0027644
protein coding gene Chr4:120771448-120846865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027471
protein coding gene Chr4:123418113-123490214 (+)
WSB/EiJ MGP_WSBEiJ_G0028003
protein coding gene Chr4:127709108-127782027 (+)



Homology
more
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Synonyms
    DAP3, SAPAP3, SPAPA3
  • Links
    NCBI Gene ID: 58512
    neXtProt AC: NX_O95886
    UniProt: O95886

  • Chr Location
    1p34.3; chr1:34865436-34929650 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042388 Ensembl Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
    transcript ENSMUST00000106094 Ensembl | MGI Sequence Detail 4207 Not Applicable  
    polypeptide ENSMUSP00000101700 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:892992
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 41
    • Earliest
      J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
    • Latest
      J:344579 Lamothe H, et al., The Sapap3(-/-) mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours. Transl Psychiatry. 2023 Jan 30;13(1):26

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory