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Ralgapa2 Gene Detail
Summary
  • Symbol
    Ralgapa2
  • Name
    Ral GTPase activating protein, alpha subunit 2 (catalytic)
  • Synonyms
    A230067G21Rik, AS250, RGC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036245
    NCBI Gene: 241694
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:146081799-146354264 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 71.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5049 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036245
 protein coding gene Chr2:146079326-146354264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026599
 protein coding gene Chr2:150421215-150701600 (-)
A/J MGP_AJ_G0026563
 protein coding gene Chr2:144319268-144593659 (-)
AKR/J MGP_AKRJ_G0026537
 protein coding gene Chr2:148530141-148812433 (-)
BALB/cJ MGP_BALBcJ_G0026575
 protein coding gene Chr2:144751779-145024753 (-)
C3H/HeJ MGP_C3HHeJ_G0026318
 protein coding gene Chr2:148997144-149275458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027020
 protein coding gene Chr2:154856602-155142285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024397
 protein coding gene Chr2:138438537-138708358 (-)
CAST/EiJ MGP_CASTEiJ_G0025779
 protein coding gene Chr2:149346512-149633061 (-)
CBA/J MGP_CBAJ_G0026298
 protein coding gene Chr2:160471881-160774752 (-)
DBA/2J MGP_DBA2J_G0026432
 protein coding gene Chr2:143621160-143893106 (-)
FVB/NJ MGP_FVBNJ_G0026396
 protein coding gene Chr2:142154153-142426906 (-)
LP/J MGP_LPJ_G0026536
 protein coding gene Chr2:150609611-150886560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026416
 protein coding gene Chr2:164662158-164959043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027075
 protein coding gene Chr2:148517345-148793699 (-)
PWK/PhJ MGP_PWKPhJ_G0025514
 protein coding gene Chr2:143299969-143576666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025315
 protein coding gene Chr2:147491810-147767554 (-)
WSB/EiJ MGP_WSBEiJ_G0025852
 protein coding gene Chr2:149446207-149728246 (-)



Homology
more
  • Human Ortholog
    RALGAPA2, Ral GTPase activating protein catalytic subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALGAPA2, Ral GTPase activating protein catalytic subunit alpha 2
  • Synonyms
    AS250, bA287B20.1, C20orf74, dJ1049G11, dJ1049G11.4, p220
  • Links
    NCBI Gene ID: 57186
    UniProt: Q2PPJ7

  • Chr Location
    chr20:20389530-20712644 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    5
  • cDNA Data
    73
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037110 Ensembl Gene Model | MGI Sequence Detail 272466 C57BL/6J ±  kb
    transcript ENSMUST00000228797 Ensembl | MGI Sequence Detail 8245 Not Applicable  
    polypeptide ENSMUSP00000153734 Ensembl | MGI Sequence Detail 1957 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000030854 Ral GTPase-activating protein subunit alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR046859 Ral GTPase-activating protein subunit alpha/beta, N-terminal domain
      IPR000331 Rap/Ran-GAP domain
      IPR035974 Rap/Ran-GAP superfamily
      IPR027107 Tuberin/Ral GTPase-activating protein subunit alpha
    • GlyGen
      A3KGS3 5 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2681868
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:306836 Iida T, et al., Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Cell Mol Gastroenterol Hepatol. 2020;9(2):277-293
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/20/2026
    MGI 6.24     		The Jackson Laboratory