Brwd3 MGI Mouse Gene Detail - MGI:3029414 - bromodomain and WD repeat domain containing 3

Symbol

Brwd3
Name

bromodomain and WD repeat domain containing 3
Synonyms

Brodl, D030064D06Rik, LOC236955

Feature Type

protein coding gene
IDs

MGI:3029414
NCBI Gene: 382236
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:107780622-107877978 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.88 cM
Mapping Data

4 experiments

SNPs within 2kb

311 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3029414	protein coding gene	ChrX:107779451-107877978 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036020	protein coding gene	ChrX:105570489-105673522 (-)
A/J	MGP_AJ_G0035999	protein coding gene	ChrX:105439638-105541254 (-)
AKR/J	MGP_AKRJ_G0035918	protein coding gene	ChrX:108719674-108826275 (-)
BALB/cJ	MGP_BALBcJ_G0035990	protein coding gene	ChrX:104120902-104217104 (-)
C3H/HeJ	MGP_C3HHeJ_G0035696	protein coding gene	ChrX:106027304-106136003 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036516	protein coding gene	ChrX:108611924-108712101 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033344	protein coding gene	ChrX:102505630-102602414 (-)
CAST/EiJ	MGP_CASTEiJ_G0034983	protein coding gene	ChrX:90079476-90182425 (-)
CBA/J	MGP_CBAJ_G0035672	protein coding gene	ChrX:112025404-112141905 (-)
DBA/2J	MGP_DBA2J_G0035826	protein coding gene	ChrX:104610644-104707521 (-)
FVB/NJ	MGP_FVBNJ_G0035766	protein coding gene	ChrX:103986586-104089382 (-)
LP/J	MGP_LPJ_G0035918	protein coding gene	ChrX:106583715-106688080 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035797	protein coding gene	ChrX:117001816-117135033 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036543	protein coding gene	ChrX:105132782-105234061 (-)
PWK/PhJ	MGP_PWKPhJ_G0034679	protein coding gene	ChrX:87593830-87692214 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034508	protein coding gene	ChrX:90906905-91011086 (-)
WSB/EiJ	MGP_WSBEiJ_G0035121	protein coding gene	ChrX:103880916-103979533 (-)

Human Ortholog

BRWD3, bromodomain and WD repeat domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BRWD3, bromodomain and WD repeat domain containing 3
Synonyms

BRODL, MRX93, XLID93
Links

HGNC:17342

NCBI Gene ID: 254065

neXtProt AC: NX_Q6RI45

UniProt: Q6RI45
Chr Location

Xq21.1; chrX:80669503-80809877 (-) GRCh38

Alliance of Genome Resources

Brwd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BRWD3
Gene Tree

Brwd3

Diseases

1 with human BRWD3 associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability 93 IDs non-syndromic X-linked intellectual disability 93 DOID:0112045 OMIM:300659

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

11
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele exhibit short tail buds, microcephaly and, in some cases, embryonic growth retardation.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase brwd3

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Brwd3 interacts with 560 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

49
RefSeq

4
UniProt

4
CCDS

CCDS41100.1

Ensembl

ENSMUSG00000063663 (Evidence)
NCBI Gene

382236

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063663	Ensembl Gene Model \| MGI Sequence Detail	97357	C57BL/6J	± kb
transcript	ENSMUST00000150434	Ensembl \| MGI Sequence Detail	11619	Not Applicable
polypeptide	ENSMUSP00000123588	Ensembl \| MGI Sequence Detail	1799	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029303 bromodomain and WD repeat-containing protein 3

(term hierarchy)
InterPro Domains

IPR001487 Bromodomain

IPR036427 Bromodomain-like superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 14

cDNA 14

Microarray probesets 2

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MGI:2443903, MGI:2685442

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:204566 Gendrel AV, et al., Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65

TSS for Brwd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164051	ChrX:107877909-107877987 (-)	30 bp
Tssr164050	ChrX:107877878-107877889 (-)	94 bp
Tssr164049	ChrX:107809026-107809029 (-)	68,950 bp
Tssr164048	ChrX:107808951-107808994 (-)	69,005 bp
Tssr164047	ChrX:107791836-107791845 (-)	86,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/26/2023 MGI 6.22