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Brwd3 Gene Detail
Summary
  • Symbol
    Brwd3
  • Name
    bromodomain and WD repeat domain containing 3
  • Synonyms
    Brodl, D030064D06Rik, LOC236955
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029414
    NCBI Gene: 382236
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:107780622-107877978 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.88 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2064 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3029414
 protein coding gene ChrX:107779451-107877978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036020
 protein coding gene ChrX:105570489-105673522 (-)
A/J MGP_AJ_G0035999
 protein coding gene ChrX:105439638-105541254 (-)
AKR/J MGP_AKRJ_G0035918
 protein coding gene ChrX:108719674-108826275 (-)
BALB/cJ MGP_BALBcJ_G0035990
 protein coding gene ChrX:104120902-104217104 (-)
C3H/HeJ MGP_C3HHeJ_G0035696
 protein coding gene ChrX:106027304-106136003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036516
 protein coding gene ChrX:108611924-108712101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033344
 protein coding gene ChrX:102505630-102602414 (-)
CAST/EiJ MGP_CASTEiJ_G0034983
 protein coding gene ChrX:90079476-90182425 (-)
CBA/J MGP_CBAJ_G0035672
 protein coding gene ChrX:112025404-112141905 (-)
DBA/2J MGP_DBA2J_G0035826
 protein coding gene ChrX:104610644-104707521 (-)
FVB/NJ MGP_FVBNJ_G0035766
 protein coding gene ChrX:103986586-104089382 (-)
LP/J MGP_LPJ_G0035918
 protein coding gene ChrX:106583715-106688080 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035797
 protein coding gene ChrX:117001816-117135033 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036543
 protein coding gene ChrX:105132782-105234061 (-)
PWK/PhJ MGP_PWKPhJ_G0034679
 protein coding gene ChrX:87593830-87692214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034508
 protein coding gene ChrX:90906905-91011086 (-)
WSB/EiJ MGP_WSBEiJ_G0035121
 protein coding gene ChrX:103880916-103979533 (-)



Homology
more
  • Human Ortholog
    BRWD3, bromodomain and WD repeat domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRWD3, bromodomain and WD repeat domain containing 3
  • Synonyms
    BRODL, DCAF20, MRX93, XLID93
  • Links
    NCBI Gene ID: 254065
    neXtProt AC: NX_Q6RI45
    UniProt: Q6RI45

  • Chr Location
    Xq21.1; chrX:80669503-80809877 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BRWD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit short tail buds, microcephaly and, in some cases, embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063663 Ensembl Gene Model | MGI Sequence Detail 97357 C57BL/6J ±  kb
    transcript ENSMUST00000150434 Ensembl | MGI Sequence Detail 11619 Not Applicable  
    polypeptide ENSMUSP00000123588 Ensembl | MGI Sequence Detail 1799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2443903, MGI:2685442
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:204566 Gendrel AV, et al., Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory