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Iqgap3 Gene Detail
Summary
  • Symbol
    Iqgap3
  • Name
    IQ motif containing GTPase activating protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028642
    NCBI Gene: 404710
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87989309-88028355 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1061 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028642
 protein coding gene Chr3:87989278-88028355 (+)
129S1/SvImJ ENSMUSG00200038175
 protein coding gene Chr3:84844127-84883209 (+)
A/J ENSMUSG00195052202
 protein coding gene Chr3:84865753-84904839 (+)
AKR/J ENSMUSG00220050864
 protein coding gene Chr3:84813859-84852939 (+)
BALB/cJ ENSMUSG00180047650
 protein coding gene Chr3:84983478-85022563 (+)
C3H/HeJ ENSMUSG00175034346
 protein coding gene Chr3:84793468-84832552 (+)
C57BL/6NJ ENSMUSG00215045248
 protein coding gene Chr3:85231843-85270916 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025155
 protein coding gene Chr3:80854387-80893990 (+)
CAST/EiJ ENSTCUG00005042025
 protein coding gene Chr3:84320063-84359385 (+)
CBA/J ENSMUSG00210044310
 protein coding gene Chr3:84936470-84975557 (+)
DBA/2J ENSMUSG00185046907
 protein coding gene Chr3:85072152-85111236 (+)
FVB/NJ ENSMUSG00205032906
 protein coding gene Chr3:83860696-83899692 (+)
JF1/MsJ ENSUMUG00000008902
 protein coding gene Chr3:84609901-84649050 (+)
LP/J ENSMUSG00230034980
 protein coding gene Chr3:87065528-87104606 (+)
NOD/ShiLtJ ENSMUSG00190035656
 protein coding gene Chr3:85312910-85351920 (+)
NZO/HlLtJ ENSMUSG00225005353
 protein coding gene Chr3:89820846-89860150 (+)
PWK/PhJ ENSLUMG00010039676
 protein coding gene Chr3:84700242-84739461 (+)
SPRET/EiJ ENSMSPG00010049790
 protein coding gene Chr3:85540405-85579676 (+)
WSB/EiJ ENSIUOG00005045714
 protein coding gene Chr3:85312648-85351721 (+)



Homology
more
  • Human Ortholog
    IQGAP3, IQ motif containing GTPase activating protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IQGAP3, IQ motif containing GTPase activating protein 3
  • Links
    NCBI Gene ID: 128239
    UniProt: Q86VI3

  • Chr Location
    1q22; chr1:156525405-156572604 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    46
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 404710 NCBI Gene Model | MGI Sequence Detail 39047 C57BL/6J ±  kb
    transcript NM_001033484 RefSeq | MGI Sequence Detail 5676 ZRU/MplStud  
    polypeptide NP_001028656 RefSeq | MGI Sequence Detail 1632 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139759
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory