Mei1 MGI Mouse Gene Detail - MGI:3028590 - meiotic double-stranded break formation protein 1

Symbol

Mei1
Name

meiotic double-stranded break formation protein 1
Synonyms

mei1

Feature Type

protein coding gene
IDs

MGI:3028590
NCBI Gene: 74369
Alliance

genome feature page

Sequence Map

Chr15:81954275-82011018 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.41 cM, cytoband E2
Mapping Data

5 experiments

SNPs within 2kb

1795 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3028590	protein coding gene	Chr15:81954197-82011018 (+)
129S1/SvImJ	ENSMUSG00200053060	protein coding gene	Chr15:79068191-79125020 (+)
A/J	ENSMUSG00195049593	protein coding gene	Chr15:78997986-79056605 (+)
AKR/J	ENSMUSG00220052630	protein coding gene	Chr15:79041130-79099761 (+)
BALB/cJ	ENSMUSG00180053146	protein coding gene	Chr15:78874938-78933551 (+)
C3H/HeJ	ENSMUSG00175043485	protein coding gene	Chr15:79185909-79244517 (+)
C57BL/6NJ	ENSMUSG00215049016	protein coding gene	Chr15:78971344-79028168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020071	protein coding gene	Chr15:76073302-76133123 (+)
CAST/EiJ	ENSTCUG00005037808	protein coding gene	Chr15:78492543-78549942 (+)
CBA/J	ENSMUSG00210044151	protein coding gene	Chr15:78961004-79019617 (+)
DBA/2J	ENSMUSG00185047619	protein coding gene	Chr15:78984211-79042821 (+)
FVB/NJ	ENSMUSG00205047560	protein coding gene	Chr15:78712635-78771399 (+)
JF1/MsJ	ENSUMUG00000046557	protein coding gene	Chr15:78563875-78619620 (+)
LP/J	ENSMUSG00230051514	protein coding gene	Chr15:82308577-82365405 (+)
NOD/ShiLtJ	ENSMUSG00190047431	protein coding gene	Chr15:78978097-79036710 (+)
NZO/HlLtJ	ENSMUSG00225049612	protein coding gene	Chr15:82645300-82703919 (+)
PWK/PhJ	ENSLUMG00010047391	protein coding gene	Chr15:78772567-78831224 (+)
SPRET/EiJ	ENSMSPG00010049977	protein coding gene	Chr15:80418040-80475520 (+)
WSB/EiJ	ENSIUOG00005047812	protein coding gene	Chr15:79053745-79110497 (+)

Human Ortholog

MEI1, meiotic double-stranded break formation protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEI1, meiotic double-stranded break formation protein 1
Synonyms

HYDM3, OZEMA26, SPATA38, SPGF103
Links

HGNC:28613

NCBI Gene ID: 150365

UniProt: Q5TIA1
Chr Location

22q13.2; chr22:41699503-41799456 (+) GRCh38

MGI Vertebrate Homology

Mei1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MEI1
Gene Tree

Mei1

Diseases

1 with human MEI1 associations

				Human Disease	Mouse Models
				gestational trophoblastic neoplasm IDs gestational trophoblastic neoplasm DOID:3590 DOID:14071 DOID:3598 ICD10CM:O01 ICD9CM:630 MESH:D006828 MESH:D031901 NCI:C3110 NCI:C4699 NCI:C7887 OMIM:231090 UMLS_CUI:C0020217 UMLS_CUI:C0278796 UMLS_CUI:C1135868

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

2
Genomic Mutations

3 involving Mei1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice of both sexes exhibit meiotic defects and are infertile.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

629
Tissues

15
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mei1

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All Sequences

54
RefSeq

14
UniProt

3
CCDS

CCDS79396.1, CCDS88810.1

Ensembl

ENSMUSG00000068117 (Evidence)
NCBI Gene

74369

			Length	Strain/Species	Flank
genomic	74369	NCBI Gene Model \| MGI Sequence Detail	56744	C57BL/6J	± kb
transcript	NM_028897	RefSeq \| MGI Sequence Detail	3991	ZRU/MplStud
polypeptide	Q9D4I2	UniProt \| EBI \| MGI Sequence Detail	1268	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031227 meiosis inhibitor protein 1

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR052133 Immune Signaling and Apoptosis Regulator

IPR060507 Meiosis inhibitor protein 1, N-terminal domain
GlyGen

Q9D4I2 1 site, 1 O-linked glycan (1 site)

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All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 3

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MGI:1890406, MGI:1921619

Summaries

All 57

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 36
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24