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Dhx37 Gene Detail
Summary
  • Symbol
    Dhx37
  • Name
    DEAH-box helicase 37
  • Synonyms
    LOC208144, LOC381671, MGC:90028
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028576
    NCBI Gene: 208144
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125490922-125511185 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 64.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    650 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028576
 protein coding gene Chr5:125490811-125511203 (-)
129S1/SvImJ ENSMUSG00200025561
 protein coding gene Chr5:119220988-119241254 (-)
A/J ENSMUSG00195009568
 protein coding gene Chr5:118742674-118762940 (-)
AKR/J ENSMUSG00220045348
 protein coding gene Chr5:118247456-118267720 (-)
BALB/cJ ENSMUSG00180032321
 protein coding gene Chr5:118857537-118877805 (-)
C3H/HeJ ENSMUSG00175029717
 protein coding gene Chr5:120853548-120873811 (-)
C57BL/6NJ ENSMUSG00215021208
 protein coding gene Chr5:118902301-118922565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027766
 protein coding gene Chr5:118382185-118402705 (-)
CAST/EiJ ENSTCUG00005038942
 protein coding gene Chr5:118139046-118159146 (-)
CBA/J ENSMUSG00210010216
 protein coding gene Chr5:119604484-119624748 (-)
DBA/2J ENSMUSG00185007198
 protein coding gene Chr5:122655547-122675810 (-)
FVB/NJ ENSMUSG00205043568
 protein coding gene Chr5:118529617-118549880 (-)
JF1/MsJ ENSUMUG00000016401
 protein coding gene Chr5:125524382-125544672 (-)
LP/J ENSMUSG00230044356
 protein coding gene Chr5:126742780-126763046 (-)
NOD/ShiLtJ ENSMUSG00190029434
 protein coding gene Chr5:118529900-118550163 (-)
NZO/HlLtJ ENSMUSG00225013970
 protein coding gene Chr5:134439696-134459966 (-)
PWK/PhJ ENSLUMG00010030954
 protein coding gene Chr5:117421633-117441922 (-)
SPRET/EiJ ENSMSPG00010038787
 protein coding gene Chr5:120714035-120734096 (-)
WSB/EiJ ENSIUOG00005017490
 protein coding gene Chr5:121236245-121256509 (-)



Homology
more
  • Human Ortholog
    DHX37, DEAH-box helicase 37
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX37, DEAH-box helicase 37
  • Synonyms
    DDX37, Dhr1, NEDBAVC, SRXY11
  • Links
    NCBI Gene ID: 57647
    UniProt: Q8IY37

  • Chr Location
    12q24.31; chr12:124946825-124989133 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DHX37 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    23
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029480 Ensembl Gene Model | MGI Sequence Detail 20264 C57BL/6J ±  kb
transcript ENSMUST00000169485 Ensembl | MGI Sequence Detail 4760 Not Applicable  
polypeptide ENSMUSP00000131734 Ensembl | MGI Sequence Detail 1150 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • PDB
    6O16
  • InterPro Domains
    IPR056371 ATP-dependent RNA helicase DHX37-like, C-terminal domain
    IPR011709 DEAD-box helicase, OB fold
    IPR011545 DEAD/DEAH-box helicase domain
    IPR007502 Helicase-associated domain
    IPR048333 Helicase associated domain (HA2), winged-helix domain
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    Q6NZL1 2 sites
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685297, MGI:2685896
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:379330 Jiang Y, et al., Multi-omics analysis the effects of Dhx37 deficiency on testis development and nucleolar homeostasis. Cell Death Discov. 2026 Jan 14;12(1):77
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory