Fam178b Gene Detail

Summary

• Symbol
  Fam178b
• Name
  family with sequence similarity 178, member B
• Synonyms
  1700024G10Rik, LOC381337, MGC:60970

• Feature Type
  protein coding gene
• IDs
  MGI:3026913
  NCBI Gene: 381337
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr1:36601773-36722264 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 15.33 cM, cytoband B
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  844 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026913	protein coding gene	Chr1:36601773-36722271 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015929	protein coding gene	Chr1:35101197-35233814 (-)
A/J	MGP_AJ_G0015913	protein coding gene	Chr1:34161040-34283555 (-)
AKR/J	MGP_AKRJ_G0015868	protein coding gene	Chr1:34643493-34762747 (-)
BALB/cJ	MGP_BALBcJ_G0015867	protein coding gene	Chr1:33850701-33972167 (-)
C3H/HeJ	MGP_C3HHeJ_G0015700	protein coding gene	Chr1:34838825-34969539 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016320	protein coding gene	Chr1:36689684-36819468 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014042	protein coding gene	Chr1:31214015-31337098 (-)
CAST/EiJ	MGP_CASTEiJ_G0015281	protein coding gene	Chr1:34725544-34851408 (-)
CBA/J	MGP_CBAJ_G0015672	protein coding gene	Chr1:37644315-37797292 (-)
DBA/2J	MGP_DBA2J_G0015773	protein coding gene	Chr1:33496468-33619634 (-)
FVB/NJ	MGP_FVBNJ_G0015775	protein coding gene	Chr1:33020371-33141327 (-)
LP/J	MGP_LPJ_G0015843	protein coding gene	Chr1:35470404-35602967 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015795	protein coding gene	Chr1:39870229-39999391 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016367	protein coding gene	Chr1:34678640-34808126 (-)
PWK/PhJ	MGP_PWKPhJ_G0015064	protein coding gene	Chr1:33249650-33373554 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014846	protein coding gene	Chr1:34627521-34759651 (-)
WSB/EiJ	MGP_WSBEiJ_G0015343	protein coding gene	Chr1:34627942-34762223 (-)

Homology

• Human Ortholog
  FAM178B, family with sequence similarity 178 member B

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FAM178B, family with sequence similarity 178 member B
  
• Links
  HGNC:28036

  NCBI Gene ID: 51252

  neXtProt AC: NX_Q8IXR5

  UniProt: Q8IXR5

  
  
• Chr Location
  2q11.2; chr2:96875882-96986580 (-)  GRCh38

---

• Alliance of Genome Resources
  Fam178b stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: FAM178B
• Gene Tree
  Fam178b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  36
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  31
• Targeted
  3
• Genomic Mutations
  1 involving Fam178b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  28

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Fam178b interacts with 38 markers (Mir28b, Mir28c, Mir92-2, ...) View All

Sequences &
Gene Models

• All Sequences
  79
• RefSeq
  33
• UniProt
  5
• CCDS
  CCDS14885.2, CCDS48241.1

• Ensembl
  ENSMUSG00000046337 (Evidence)
• NCBI Gene
  381337

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046337	Ensembl Gene Model | MGI Sequence Detail	120492	C57BL/6J
transcript	ENSMUST00000170295	Ensembl | MGI Sequence Detail	2286	Not Applicable
polypeptide	ENSMUSP00000132846	Ensembl | MGI Sequence Detail	523	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000031861 protein FAM178B
  (term hierarchy)
• InterPro Domains
  IPR044276 Coiled-coil SMC6 And NSE5 INteracting (CANIN) domain
  IPR026161 FAM178 family

Molecular
Reagents

• All nucleic 28

  cDNA 28

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1919099, MGI:2685836

References

• Summaries
  All 31

  Phenotypes 9
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Fam178b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11271	Chr1:36722196-36722235 (-)	48 bp
Tssr11270	Chr1:36722178-36722189 (-)	80 bp
Tssr11269	Chr1:36683058-36683089 (-)	39,190 bp
Tssr11268	Chr1:36632396-36632419 (-)	89,856 bp
Tssr11267	Chr1:36604692-36604694 (-)	117,571 bp