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Zfyve1 Gene Detail
Summary
  • Symbol
    Zfyve1
  • Name
    zinc finger, FYVE domain containing 1
  • Synonyms
    mKIAA1589
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026685
    NCBI Gene: 217695
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:83593332-83643996 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 38.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026685
protein coding gene Chr12:83593330-83679289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019914
protein coding gene Chr12:84187593-84241474 (-)
A/J MGP_AJ_G0019871
protein coding gene Chr12:80998678-81050694 (-)
AKR/J MGP_AKRJ_G0019847
protein coding gene Chr12:83187975-83239083 (-)
BALB/cJ MGP_BALBcJ_G0019851
protein coding gene Chr12:81350139-81404712 (-)
C3H/HeJ MGP_C3HHeJ_G0019657
protein coding gene Chr12:83657863-83708416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020303
protein coding gene Chr12:86586508-86653003 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017920
protein coding gene Chr12:77927042-77978098 (-)
CAST/EiJ MGP_CASTEiJ_G0019206
protein coding gene Chr12:78596760-78649583 (-)
CBA/J MGP_CBAJ_G0019628
protein coding gene Chr12:89931544-89983552 (-)
DBA/2J MGP_DBA2J_G0019743
protein coding gene Chr12:80549446-80600560 (-)
FVB/NJ MGP_FVBNJ_G0019729
protein coding gene Chr12:79491795-79542314 (-)
LP/J MGP_LPJ_G0019815
protein coding gene Chr12:84060767-84112636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019768
protein coding gene Chr12:92901244-92957406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020337
protein coding gene Chr12:82785597-82839254 (-)
PWK/PhJ MGP_PWKPhJ_G0018970
protein coding gene Chr12:75024013-75076119 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018765
protein coding gene Chr12:77248308-77301180 (-)
WSB/EiJ MGP_WSBEiJ_G0019258
protein coding gene Chr12:83449756-83505494 (-)



Homology
more
  • Human Ortholog
    ZFYVE1, zinc finger FYVE-type containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFYVE1, zinc finger FYVE-type containing 1
  • Synonyms
    DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1
  • Links
    NCBI Gene ID: 53349
    neXtProt AC: NX_Q9HBF4
    UniProt: Q9HBF4

  • Chr Location
    14q24.2; chr14:72969445-73027131 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced susceptibility to EMCV-treated mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042628 Ensembl Gene Model | MGI Sequence Detail 50665 C57BL/6J ±  kb
transcript ENSMUST00000048319 Ensembl | MGI Sequence Detail 4036 Not Applicable  
polypeptide ENSMUSP00000042224 Ensembl | MGI Sequence Detail 777 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032428 zinc finger FYVE domain-containing protein 1
  • InterPro Domains
    IPR000306 FYVE zinc finger
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR042427 Zinc finger FYVE domain-containing protein 1
    IPR047856 Zinc finger FYVE domain-containing protein 1, first B-box-type 1 domain
    IPR047855 Zinc finger FYVE domain-containing protein 1, second B-box-type 1
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR017455 Zinc finger, FYVE-related
    IPR013083 Zinc finger, RING/FYVE/PHD-type
  • GlyGen
    Q810J8 3 sites, 1 O-linked glycan (3 sites)
Molecular
Reagents
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  • All nucleic 82
    cDNA 82

    Microarray probesets 5
References
more
  • Summaries
    All 41
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory