Tmt1a2 Gene Detail

Summary

• Symbol
  Tmt1a2
• Name
  thiol methyltransferase 1A2
• Synonyms
  Mettl7a2, Ubie

• Feature Type
  protein coding gene
• IDs
  MGI:3026615
  NCBI Gene: 393082
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr15:100251081-100259700 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.27 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  436 from dbSNP Build 142
• Strain Annotations
  12

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026615	protein coding gene	Chr15:100251081-100259721 (+)
129S1/SvImJ	ENSMUSG00200049944	protein coding gene	Chr15:97456911-97465542 (+)
A/J	ENSMUSG00195041706	protein coding gene	Chr15:97334429-97343073 (+)
AKR/J	ENSMUSG00220046265	protein coding gene	Chr15:97327664-97336310 (+)
BALB/cJ	ENSMUSG00180040506	protein coding gene	Chr15:97232737-97241368 (+)
C3H/HeJ	ENSMUSG00175040182	protein coding gene	Chr15:97514414-97523056 (+)
C57BL/6NJ	ENSMUSG00215049352	protein coding gene	Chr15:97289507-97298149 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020287	protein coding gene	Chr15:94047054-94052469 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210028120	protein coding gene	Chr15:97289585-97298216 (+)
DBA/2J	ENSMUSG00185038860	protein coding gene	Chr15:97334022-97342662 (+)
FVB/NJ	ENSMUSG00205021563	protein coding gene	Chr15:97038523-97047163 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230039291	protein coding gene	Chr15:100680255-100688886 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  TMT1A, thiol methyltransferase 1A

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMT1A, thiol methyltransferase 1A
  
• Synonyms
  AAM-B, AAMB, METTL7A
• Links
  HGNC:24550

  NCBI Gene ID: 25840

  UniProt: Q9H8H3

  
  
• Chr Location
  12q13.12; chr12:50923472-50932510 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmt1a2 stringent orthology
  1 human;1 mouse;1 rat;3 zebrafish
  
• HCOP
  vertebrate homology predictions: TMT1A
• Gene Tree
  Tmt1a2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Radiation induced
  2
• Genomic Mutations
  3 involving Tmt1a2
• Find Mice (IMSR)
  2 strains or lines available

Expression

• Assay Results
  597
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS27836.1

• Ensembl
  ENSMUSG00000056487 (Evidence)
• NCBI Gene
  393082

Representative Sequences			Length	Strain/Species
genomic	393082	NCBI Gene Model | MGI Sequence Detail	8620	C57BL/6J
transcript	NM_199477	RefSeq | MGI Sequence Detail	1808	Not Specified
polypeptide	NP_955771	RefSeq | MGI Sequence Detail	244	Not Specified

Protein
Information

• UniProt
  2 Sequences

Molecular
Reagents

• All nucleic 3

  cDNA 3

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:7461485

References

• Summaries
  All 33

  Diseases 1

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)