Tmt1a2 Gene Detail

Summary

• Symbol
  Tmt1a2
• Name
  thiol methyltransferase 1A2
• Synonyms
  Mettl7a2, Ubie

• Feature Type
  protein coding gene
• IDs
  MGI:3026615
  NCBI Gene: 393082
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr15:100251081-100259700 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.27 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  436 from dbSNP Build 142
• Strain Annotations
  14

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026615	protein coding gene	Chr15:100251081-100259721 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	MGP_AKRJ_G0022285	protein coding gene	Chr15:101187494-101204929 (+)
BALB/cJ	MGP_BALBcJ_G0022314	protein coding gene	Chr15:98334521-98350718 (+)
C3H/HeJ	MGP_C3HHeJ_G0022084	protein coding gene	Chr15:101295323-101303256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022761	protein coding gene	Chr15:106053394-106062085 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020287	protein coding gene	Chr15:94047054-94052469 (+)
CAST/EiJ	MGP_CASTEiJ_G0021608	protein coding gene	Chr15:102136918-102149114 (+)
CBA/J	MGP_CBAJ_G0022053	protein coding gene	Chr15:109766152-109783377 (+)
DBA/2J	MGP_DBA2J_G0022179	protein coding gene	Chr15:97580141-97594032 (+)
FVB/NJ	MGP_FVBNJ_G0022160	protein coding gene	Chr15:96573758-96582313 (+)
LP/J	MGP_LPJ_G0022251	protein coding gene	Chr15:102380979-102398484 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022180	protein coding gene	Chr15:113517221-113527060 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022776	protein coding gene	Chr15:101285399-101294901 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0021658	protein coding gene	Chr15:101819523-101827963 (+)

Homology

• Human Ortholog
  TMT1A, thiol methyltransferase 1A

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMT1A, thiol methyltransferase 1A
  
• Synonyms
  AAM-B, AAMB, METTL7A
• Links
  HGNC:24550

  NCBI Gene ID: 25840

  UniProt: Q9H8H3

  
  
• Chr Location
  12q13.12; chr12:50923472-50932510 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmt1a2 stringent orthology
  1 human;1 mouse;1 rat;3 zebrafish
  
• HCOP
  vertebrate homology predictions: TMT1A
• Gene Tree
  Tmt1a2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Radiation induced
  2
• Genomic Mutations
  3 involving Tmt1a2
• Find Mice (IMSR)
  2 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS27836.1

• Ensembl
  ENSMUSG00000056487 (Evidence)
• NCBI Gene
  393082

Representative Sequences			Length	Strain/Species
genomic	393082	NCBI Gene Model | MGI Sequence Detail	8620	C57BL/6J
transcript	NM_199477	RefSeq | MGI Sequence Detail	1808	Not Specified
polypeptide	NP_955771	RefSeq | MGI Sequence Detail	244	Not Specified

Protein
Information

• UniProt
  2 Sequences

Molecular
Reagents

• All nucleic 3

  cDNA 3

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:7461485

References

• Summaries
  All 32

  Diseases 1

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)